ZM 306416
Modify Date: 2025-08-21 18:00:55
ZM 306416 structure
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Common Name | ZM 306416 | ||
|---|---|---|---|---|
| CAS Number | 690206-97-4 | Molecular Weight | 333.745 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 434.1±45.0 °C at 760 mmHg | |
| Molecular Formula | C16H13ClFN3O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 216.4±28.7 °C | |
Use of ZM 306416ZM-306416 (CB 676475) is a potent inhibitor of VEGFR with IC50s of 0.1 and 2 μM for KDR and Flt, respectively. ZM-306416 is also a EGFR inhibitor with an IC50 of <10 nM. |
| Name | N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine |
|---|---|
| Synonym | More Synonyms |
| Description | ZM-306416 (CB 676475) is a potent inhibitor of VEGFR with IC50s of 0.1 and 2 μM for KDR and Flt, respectively. ZM-306416 is also a EGFR inhibitor with an IC50 of <10 nM. |
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| Related Catalog | |
| Target |
KDR:100 nM (IC50) Flt-1:2 μM (IC50) |
| In Vitro | ZM-306416 selective anti-proliferative effect toward the EGFR addicted NSCLC cell lines H3255 and HCC4011 (IC50=0.09±0.007 μM and 0.072±0.001 μM respectively), while sparing the wild type EGFR cell lines A549 and H2030 (IC50>10 μM). ZM-306416 is also found to inhibit the ABL in vitro kinase activity with a less potent IC50 value of 1.3±0.2 μM toward the ABL kinase[2]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 434.1±45.0 °C at 760 mmHg |
| Molecular Formula | C16H13ClFN3O2 |
| Molecular Weight | 333.745 |
| Flash Point | 216.4±28.7 °C |
| Exact Mass | 333.068024 |
| PSA | 56.27000 |
| LogP | 4.15 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.653 |
| InChIKey | YHUIUSRCUKUUQA-UHFFFAOYSA-N |
| SMILES | COc1cc2ncnc(Nc3ccc(Cl)cc3F)c2cc1OC |
| Storage condition | Desiccate at RT |
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Name: Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro...
Source: NCGC
Target: N/A
External Id: SERCaMPGLuc-p1-antagonist
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Name: Vascular endothelial growth factor receptor 2 inhibitory activity at 2 uM of ATP in v...
Source: ChEMBL
Target: Vascular endothelial growth factor receptor 2
External Id: CHEMBL812620
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Name: Human epidermal growth factor receptor (Type I RTKs: ErbB (epidermal growth factor) r...
Source: IUPHAR-DB
Target: epidermal growth factor receptor (Type I RTKs: ErbB (epidermal growth factor) receptor family) [Homo sapiens]
External Id: 1797_Human
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|
Name: SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f...
Source: ChEMBL
Target: Replicase polyprotein 1ab
External Id: CHEMBL4495582
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|
Name: Percent inhibition of VEGF-mediated estradiol benzoate-induced rat uterus weight gain...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL800092
|
|
Name: Inhibition of VEGFR1 tyrosine kinase activity in VEGF-stimulated human A498 cells aft...
Source: ChEMBL
Target: Vascular endothelial growth factor receptor 1
External Id: CHEMBL1932341
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|
Name: Enzymatic assay of human HDAC6 with commercial peptide substrate
Source: ChEMBL
Target: Histone deacetylase 6
External Id: CHEMBL4808149
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Name: EZH2/PRC2 methyltransferase inhibitors Measured in Biochemical System Using Plate Rea...
Source: Broad Institute
Target: histone-lysine N-methyltransferase EZH2 isoform a [Homo sapiens]
External Id: 2125-01_Inhibitor_SinglePoint_HTS_Activity
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Name: Enzymatic assay of human HDAC6 with custom peptide substrate
Source: ChEMBL
Target: Histone deacetylase 6
External Id: CHEMBL4808150
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Name: Inhibition of N-terminal GST-tagged recombinant human MKK3 S198E/T193E mutant express...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5550262
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| N-(4-Chloro-2-fluorophenyl)-6,7-dimethoxy-4-quinazolinamine |
| N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine |
| Anilinoquinazoline deriv. 4 |
| ZM-306416 |
| ZM306416 |
| ZM 306416 |