690206-97-4
690206-97-4 structure
- Name: ZM 306416
- Chemical Name: N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine
- CAS Number: 690206-97-4
- Molecular Formula: C16H13ClFN3O2
- Molecular Weight: 333.745
- Catalog: Biochemical Inhibitor Protein tyrosine kinase
- Create Date: 2016-10-10 19:47:45
- Modify Date: 2024-01-09 17:21:07
-
ZM-306416 (CB 676475) is a potent inhibitor of VEGFR with IC50s of 0.1 and 2 μM for KDR and Flt, respectively. ZM-306416 is also a EGFR inhibitor with an IC50 of <10 nM.
| Name | N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine |
|---|---|
| Synonyms |
4-Quinazolinamine, N-(4-chloro-2-fluorophenyl)-6,7-dimethoxy-
N-(4-Chloro-2-fluorophenyl)-6,7-dimethoxy-4-quinazolinamine N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine Anilinoquinazoline deriv. 4 ZM-306416 ZM306416 ZM 306416 |
| Description | ZM-306416 (CB 676475) is a potent inhibitor of VEGFR with IC50s of 0.1 and 2 μM for KDR and Flt, respectively. ZM-306416 is also a EGFR inhibitor with an IC50 of <10 nM. |
|---|---|
| Related Catalog | |
| Target |
KDR:100 nM (IC50) Flt-1:2 μM (IC50) |
| In Vitro | ZM-306416 selective anti-proliferative effect toward the EGFR addicted NSCLC cell lines H3255 and HCC4011 (IC50=0.09±0.007 μM and 0.072±0.001 μM respectively), while sparing the wild type EGFR cell lines A549 and H2030 (IC50>10 μM). ZM-306416 is also found to inhibit the ABL in vitro kinase activity with a less potent IC50 value of 1.3±0.2 μM toward the ABL kinase[2]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 434.1±45.0 °C at 760 mmHg |
| Molecular Formula | C16H13ClFN3O2 |
| Molecular Weight | 333.745 |
| Flash Point | 216.4±28.7 °C |
| Exact Mass | 333.068024 |
| PSA | 56.27000 |
| LogP | 4.15 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.653 |
| Storage condition | Desiccate at RT |