Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride (ZM 306416)
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Purity: 98.0%
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690206-97-4

690206-97-4 structure

Name: ZM 306416
Chemical Name: N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine
CAS Number: 690206-97-4
Molecular Formula: C₁₆H₁₃ClFN₃O₂
Molecular Weight: 333.745
Catalog: Biochemical Inhibitor Protein tyrosine kinase
Create Date: 2016-10-10 19:47:45
Modify Date: 2026-07-09 12:21:58
ZM-306416 (CB 676475) is a potent inhibitor of VEGFR with IC50s of 0.1 and 2 μM for KDR and Flt, respectively. ZM-306416 is also a EGFR inhibitor with an IC50 of <10 nM.

Name	N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine
Synonyms	N-(3-chloro-4-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine N-(4-Chloro-2-fluorophenyl)-6,7-dimethoxy-4-quinazolinamine ZM306416/ZM-306416 ZM 306416 ，S2897 ZM 306416 //BP ZM 213689 DisodiuM Salt (MeropeneM iMpurity) 4-QuinazolinaMine,N-(4-chloro-2-fluorophenyl)-6,7-diMethoxy ZM 306416, 10 mM in DMSO ZM-306416;ZM 306416;CB 676475;ZM-306416;ZM306416;CB-676475;CB 4-[(4'-CHLORO-2'-FLUORO)PHENYLAMINO]-6,7-DIMETHOXYQUINAZOLINE HYDROCHLORIDE Anilinoquinazoline deriv. 4 ZM 213689 DisodiuM Salt (MeropeneM iMpurity) (Mixture of double bond isoMers) ZM-306416,CB-676475,VEGFR,Inhibitor,ZM 306416,ZM306416,CB676475,inhibit,Vascul endothelial owth factor rector ZM 306416 HYDROCHLORIDE Gefitinib Impurity ZM 306416, >= ZM-306416 ZM306416 CB-676475 N-(4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine

Description	ZM-306416 (CB 676475) is a potent inhibitor of VEGFR with IC50s of 0.1 and 2 μM for KDR and Flt, respectively. ZM-306416 is also a EGFR inhibitor with an IC50 of <10 nM.
Related Catalog	Research Areas >> Cancer
Target	KDR:100 nM (IC50) Flt-1:2 μM (IC50)
In Vitro	ZM-306416 selective anti-proliferative effect toward the EGFR addicted NSCLC cell lines H3255 and HCC4011 (IC50=0.09±0.007 μM and 0.072±0.001 μM respectively), while sparing the wild type EGFR cell lines A549 and H2030 (IC50>10 μM). ZM-306416 is also found to inhibit the ABL in vitro kinase activity with a less potent IC50 value of 1.3±0.2 μM toward the ABL kinase[2].
References	[1]. Han SY, Park SS, Lee WG, Synthesis of a novel biotin-tagged photoaffinity probe for VEGF receptor tyrosine kinases. Bioorg Med Chem Lett. 2006 Jan 1;16(1):129-33. [2]. Antczak C, Mahida JP, Bhinder B, A high-content biosensor-based screen identifies cell-permeable activators and inhibitors of EGFR function: implications in drug discovery. J Biomol Screen. 2012 Aug;17(7):885-99.