Ozagrel hydrochloride
Ozagrel hydrochloride structure
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Common Name | Ozagrel hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 78712-43-3 | Molecular Weight | 282.723 | |
| Density | N/A | Boiling Point | 468ºC at 760 mmHg | |
| Molecular Formula | C13H15ClN2O3 | Melting Point | 217 °C | |
| MSDS | Chinese USA | Flash Point | 236.8ºC | |
Use of Ozagrel hydrochlorideOzagrel hydrochloride (OKY-046 hydrochloride) is a thromboxane A2 (TXA2) synthase inhibitor. Ozagrel hydrochloride is an antiplatelet agent, which selectively inhibits human platelet aggregationwith an IC50 of 53.12 μM[1]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | Ozagrel Hydrochloride Hydrate |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Ozagrel hydrochloride (OKY-046 hydrochloride) is a thromboxane A2 (TXA2) synthase inhibitor. Ozagrel hydrochloride is an antiplatelet agent, which selectively inhibits human platelet aggregationwith an IC50 of 53.12 μM[1]. |
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| Related Catalog | |
| Target |
TXA2 |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Boiling Point | 468ºC at 760 mmHg |
|---|---|
| Melting Point | 217 °C |
| Molecular Formula | C13H15ClN2O3 |
| Molecular Weight | 282.723 |
| Flash Point | 236.8ºC |
| Exact Mass | 282.077118 |
| PSA | 64.35000 |
| LogP | 2.76690 |
| InChIKey | CWKFWBJJNNPGAM-IPZCTEOASA-N |
| SMILES | Cl.O=C(O)C=Cc1ccc(Cn2ccnc2)cc1 |
| Water Solubility | H2O: soluble |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| RTECS | UD3380000 |
| HS Code | 2942000000 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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~88%
Ozagrel hydroch... CAS#:78712-43-3 |
| Literature: Yu, Chenglong; Zhao, Baohai; Zhao, Yihong; Lin, Jimao Organic Preparations and Procedures International, 2010 , vol. 42, # 2 p. 183 - 185 |
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~68%
Ozagrel hydroch... CAS#:78712-43-3 |
| Literature: Yamada, Yoichi M. A.; Yuyama, Yoshinari; Sato, Takuma; Fujikawa, Shigenori; Uozumi, Yasuhiro Angewandte Chemie - International Edition, 2014 , vol. 53, # 1 p. 127 - 131 Angew. Chem., 2014 , vol. 126, # 01 p. 5131 - 5135 |
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~%
Ozagrel hydroch... CAS#:78712-43-3 |
| Literature: Angewandte Chemie - International Edition, , vol. 53, # 1 p. 127 - 131 Angew. Chem., , vol. 126, # 01 p. 5131 - 5135 |
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~%
Ozagrel hydroch... CAS#:78712-43-3 |
| Literature: Angewandte Chemie - International Edition, , vol. 53, # 1 p. 127 - 131 Angew. Chem., , vol. 126, # 01 p. 5131 - 5135 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 4 | |
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| DownStream 0 | |
This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2942000000 |
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This table lists relevant public references with title, journal and publication metadata for this compound.
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Adhesion of platelets through thromboxane A₂ receptor signaling facilitates liver repair during acute chemical-induced hepatotoxicity.
Life Sci. 132 , 85-92, (2015) Platelets have been suggested to play an important role in liver regeneration and repair after hepatic resection and acute liver injury. However, the underlying mechanisms of liver repair remain elusi... |
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BLT2 up-regulates interleukin-8 production and promotes the invasiveness of breast cancer cells.
PLoS ONE 7 , e49186, (2012) The elevated production of interleukin (IL)-8 is critically associated with invasiveness and metastatic potential in breast cancer cells. However, the intracellular signaling pathway responsible for u... |
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Safety and efficacy of fasudil monotherapy and fasudil-ozagrel combination therapy in patients with subarachnoid hemorrhage: sub-analysis of the post-marketing surveillance study.
Neurol. Med. Chir. (Tokyo) 48(6) , 241-7; discussion 247-8, (2008) Sub-analysis of the fasudil post-marketing surveillance study compared the safety and efficacy of fasudil plus ozagrel to fasudil only. A total of 3690 patients received fasudil and 1138 received fasu... |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| (2E)-3-[4-(1H-Imidazol-1-ylmethyl)phenyl]acrylic acid hydrochloride hydrate |
| Ozagrel hydrochloride |
| 2-Propenoic acid, 3-[4-(1H-imidazol-1-ylmethyl)phenyl]-, (2E)-, hydrochloride, hydrate (1:1:1) |
| MFCD06795644 |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What English synonyms does Ozagrel Hydrochloride Hydrate have? |
| A: English synonyms of Ozagrel Hydrochloride Hydrate: (2E)-3-[4-(1H-Imidazol-1-ylmethyl)phenyl]acrylic acid hydrochloride hydrate, Ozagrel hydrochloride, 2-Propenoic acid, 3-[4-(1H-imidazol-1-ylmethyl)phenyl]-, (2E)-, hydrochloride, hydrate (1:1:1), MFCD06795644. |
| Q: What is the InChIKey of Ozagrel Hydrochloride Hydrate? |
| A: InChIKey of Ozagrel Hydrochloride Hydrate is CWKFWBJJNNPGAM-IPZCTEOASA-N. |
| Q: What is the LogP of Ozagrel Hydrochloride Hydrate? |
| A: LogP of Ozagrel Hydrochloride Hydrate is 2.76690. |
| Q: How is the water solubility of Ozagrel Hydrochloride Hydrate? |
| A: Water solubility of Ozagrel Hydrochloride Hydrate: H2O: soluble. |
| Q: What is the polar surface area (PSA) of Ozagrel Hydrochloride Hydrate? |
| A: Polar surface area (PSA) of Ozagrel Hydrochloride Hydrate is 64.35000. |
| Q: What is the melting point of Ozagrel Hydrochloride Hydrate? |
| A: Melting point of Ozagrel Hydrochloride Hydrate is 217 °C. |
| Q: What are the upstream materials of Ozagrel Hydrochloride Hydrate? |
| A: Related upstream materials(CAS) of Ozagrel Hydrochloride Hydrate: 141-82-2;102432-03-1;1145685-38-6;18282-51-4. |
| Q: What are the uses of Ozagrel Hydrochloride Hydrate? |
| A: Main uses of Ozagrel Hydrochloride Hydrate: Ozagrel hydrochloride (OKY-046 hydrochloride) is a thromboxane A2 (TXA2) synthase inhibitor. Ozagrel hydrochloride is an antiplatelet agent, which selectively inhibits human platelet aggregationwith an IC50 of 53.12 μM[1]. |
| Q: What is the SMILES notation of Ozagrel Hydrochloride Hydrate? |
| A: SMILES notation of Ozagrel Hydrochloride Hydrate is Cl.O=C(O)C=Cc1ccc(Cn2ccnc2)cc1. |
| Q: What is the boiling point of Ozagrel Hydrochloride Hydrate? |
| A: Boiling point of Ozagrel Hydrochloride Hydrate is 468ºC at 760 mmHg. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |