Ozagrel hydrochloride
Ozagrel hydrochloride structure
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Common Name | Ozagrel hydrochloride | ||
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| CAS Number | 78712-43-3 | Molecular Weight | 282.723 | |
| Density | N/A | Boiling Point | 468ºC at 760 mmHg | |
| Molecular Formula | C13H15ClN2O3 | Melting Point | 217 °C | |
| MSDS | Chinese USA | Flash Point | 236.8ºC | |
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Adhesion of platelets through thromboxane A₂ receptor signaling facilitates liver repair during acute chemical-induced hepatotoxicity.
Life Sci. 132 , 85-92, (2015) Platelets have been suggested to play an important role in liver regeneration and repair after hepatic resection and acute liver injury. However, the underlying mechanisms of liver repair remain elusive. Signaling through thromboxane prostanoid (TP) receptor ... |
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BLT2 up-regulates interleukin-8 production and promotes the invasiveness of breast cancer cells.
PLoS ONE 7 , e49186, (2012) The elevated production of interleukin (IL)-8 is critically associated with invasiveness and metastatic potential in breast cancer cells. However, the intracellular signaling pathway responsible for up-regulation of IL-8 production in breast cancer cells has ... |
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Safety and efficacy of fasudil monotherapy and fasudil-ozagrel combination therapy in patients with subarachnoid hemorrhage: sub-analysis of the post-marketing surveillance study.
Neurol. Med. Chir. (Tokyo) 48(6) , 241-7; discussion 247-8, (2008) Sub-analysis of the fasudil post-marketing surveillance study compared the safety and efficacy of fasudil plus ozagrel to fasudil only. A total of 3690 patients received fasudil and 1138 received fasudil plus ozagrel between 1995 and 2000. The occurrence of a... |
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A prostacyclin agonist with thromboxane inhibitory activity for airway allergic inflammation in mice.
Clin. Exp. Allergy 40(2) , 317-26, (2010) ONO-1301 is a novel drug that acts as a prostacyclin agonist with thromboxane A(2) (TxA(2)) synthase inhibitory activity. We investigated the effect of ONO-1301 on development of airway allergic inflammation.Mice sensitized and challenged to ovalbumin (OVA) r... |
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A selective thromboxane A2 (TXA2) synthase inhibitor, ozagrel, attenuates lung injury and decreases monocyte chemoattractant protein-1 and interleukin-8 mRNA expression in oleic acid-induced lung injury in guinea pigs.
J. Pharmacol. Sci. 111(2) , 211-5, (2009) This study examined the effect of ozagrel, a thromboxane A(2) synthase inhibitor, on the accumulation of leucocytes and chemokine mRNA expression in lungs experimentally injured using oleic acid (OA). OA injection into guinea pigs rapidly increased thromboxan... |
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Abnormalities of endothelium-dependent responses in mesenteric arteries from Otsuka Long-Evans Tokushima Fatty (OLETF) rats are improved by chronic treatment with thromboxane A2 synthase inhibitor.
Atherosclerosis 205(1) , 87-95, (2009) Thromboxane A(2) (TXA(2)) is thought to contribute to the development of diabetic complications. We tested the hypothesis that the impaired endothelial function seen in Otsuka Long-Evans Tokushima Fatty (OLETF) rats (a type 2 diabetic model) might be improved... |
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Losartan and ozagrel reverse retinal arteriolar constriction in non-obese diabetic mice.
Microcirculation 15(5) , 379-87, (2008) Reductions in retinal blood flow are observed early in diabetes. Venules may influence arteriolar constriction and flow; therefore, we hypothesized that diabetes would induce the constriction of arterioles that are in close proximity to venules, with the cons... |
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Ozagrel reverses streptozotocin-induced constriction of arterioles in rat retina.
Microvasc. Res. 76(3) , 217-23, (2008) Retinal blood flow decreases early in the progression of diabetic retinopathy; however, the mediators and mechanisms responsible for this decrease have yet to be determined. In this study, diabetes was induced by streptozotocin in rats, and retinal blood flow... |
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Effect of cilostazol in the treatment of acute ischemic stroke in the lenticulostriate artery territory.
Eur. Neurol. 69(2) , 122-8, (2013) Cilostazol, an inhibitor of phosphodiesterase 3, has various pleiotropic effects besides its antiplatelet activity. This study examined the efficacy of cilostazol for the treatment of acute perforating artery infarction.In this prospective, randomized, open-l... |
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Ozagrel hydrochloride, a selective thromboxane A₂ synthase inhibitor, alleviates liver injury induced by acetaminophen overdose in mice.
BMC Gastroenterol. 13 , 21, (2013) Overdosed acetaminophen (paracetamol, N-acetyl-p-aminophenol; APAP) causes severe liver injury. We examined the effects of ozagrel, a selective thromboxane A2 (TXA2) synthase inhibitor, on liver injury induced by APAP overdose in mice.Hepatotoxicity was induc... |