LEO 134310
Published date: 2022-06-22 21:57:40
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Name | LEO 134310 | CAS# | 2089130-74-3 |
|---|---|---|---|---|
| Price | $Inquiry/100mg $Inquiry/250mg $Inquiry/1g | Purity | 98.0% | |
| Stocking Period |
3 Day | Stock | 3 | |
| Product Webpage: | https://www.dcchemicals.com/product_show-leo134310.html | |||
| Detail
Product Information
LEO 134310 (LP 0155) is a non-steroidal, potent and selective glucocorticoid receptor (GR) agonist (EC50=2 nM, hPBMC).LEO 134310 is rapidly deactivated in the blood resulting in low systemic exposure and a higher therapeutic index in the TPA-induced skin inflammation mouse model compared with betamethasone valerate (BMV) and clobetasol propionate (CP).LEO 134310 displays high selectivity for GR in a panel of nuclear receptors, including the mineralocorticoid receptor (MR).LEO 134310 exhibits full efficacy on GR transactivation and transrepression.LEO 134310 may be suitable for long-term topical treatment of inflammatory skin diseases. |
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