JNJ-40418677

Published date: 2022-11-29 15:44:27
JNJ-40418677 Structure
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Name JNJ-40418677 CAS# 1146594-87-7
Price ￥Inquiry/1g Purity 98.9%
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Period		 1 Day Stock In Stock
 Detail Product Information
JNJ-40418677 is a γ-secretase modulator that selectively blocks γ-site cleavage of the APP without affecting processing of Notch. In human neuroblastoma cells and rat primary neuronal cultures, JNJ-40418677 blocked secretion of Aβb42 (IC50 = 20 nM), with no affects on total Ab concentration, Notch signaling or COX activity. In vivo experiments showed that JNJ-40418677 dose dependently inhibited Aβ42 accumulation in the brain while promoting an increase in Aβ38.
Supplier/Manufacture

ShangHai DC Chemicals Co.,Ltd verified supplier

Chemsrc Level: Verified
Product #: 14107
Tel: 58447131
Address: Pudong new area Jin Yu road 100#
Area: China
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Website: http://www.biomedgen.cn
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