LY-3537982

Published date: 2022-11-29 15:44:27
LY-3537982 Structure
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Name LY-3537982 CAS# 2414198-64-2
Price ￥Inquiry/1g Purity 98.9%
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Period		 1 Day Stock In Stock
 Detail Product Information
LY-3537982 (LY3537982) is a highly selective and potent KRAS-G12C inhibitor, selectively inhibits growth of KRAS G12C mutant cells (IC50=1-60 nM).LY-3537982 does not inhibit growth of KRAS G12S/G13C/G12D mutant cells and WT KRAS cells (CI50>10 uM).LY-3537982 displays high selectivity for proteome-wide cysteine residues was evaluated using competitive chemical proteomics (8866 peptides).LY3537982 inhibits the growth of subcutaneous EL3187 NSCLC PDX tumors in nude mice in a dose dependent manner.LY3537982 demonstrates robust tumor regression in combination with other agents in KRAS G12C in vivo models.LY3537982 is a promising KRAS G12C inhibitor predicted to deliver >90% KRAS G12C target occupancy in the clinic.
Supplier/Manufacture

ShangHai DC Chemicals Co.,Ltd verified supplier

Chemsrc Level: Verified
Product #: 14107
Tel: 58447131
Address: Pudong new area Jin Yu road 100#
Area: China
Contact: Tony Lai
Contact Phone #: 13564518121
Email: order@dcchemicals.com
Website: http://www.biomedgen.cn
Foreign Trade % of Sales: 20%
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2024-07-17 LY-3537982
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2022-06-22 LY-3537982
Price: $950.0
2022-05-12 2414198-64-2
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