5-Hydroxy-4-methoxycanthin-6-one

Modify Date: 2025-08-26 21:25:09

5-Hydroxy-4-methoxycanthin-6-one Structure
5-Hydroxy-4-methoxycanthin-6-one structure
Common Name 5-Hydroxy-4-methoxycanthin-6-one
CAS Number 18110-86-6 Molecular Weight 266.251
Density 1.5±0.1 g/cm3 Boiling Point 442.7±45.0 °C at 760 mmHg
Molecular Formula C15H10N2O3 Melting Point N/A
MSDS N/A Flash Point 221.5±28.7 °C

 Use of 5-Hydroxy-4-methoxycanthin-6-one


Nigakinone is one of the most abundant alkaloids responsible for the major pharmacological activities of Kumu.

 Names

Name Nigakinone
Synonym More Synonyms

 5-Hydroxy-4-methoxycanthin-6-one Biological Activity

Description Nigakinone is one of the most abundant alkaloids responsible for the major pharmacological activities of Kumu.
Related Catalog
References

[1]. Wang N, et al. Quality Assessment of Kumu Injection, a Traditional Chinese Medicine Preparation, Using HPLC Combined with Chemometric Methods and Qualitative and Quantitative Analysis of Multiple Alkaloids by Single Marker. Molecules. 2018 Apr 9;23(4).

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 442.7±45.0 °C at 760 mmHg
Molecular Formula C15H10N2O3
Molecular Weight 266.251
Flash Point 221.5±28.7 °C
Exact Mass 266.069153
PSA 63.83000
LogP 1.92
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.747
InChIKey PGFKZUOYIFDMQJ-UHFFFAOYSA-N
SMILES COc1c(O)c(=O)n2c3ccccc3c3ccnc1c32

 Safety Information

Hazard Codes Xi
HS Code 2933990090

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 5-Hydroxy-4-methoxycanthin-6-oneBioassay

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Name: Primary cell-based high-throughput screening assay for identification of compounds th...
Source: Johns Hopkins Ion Channel Center
Target: regulator of G-protein signaling 4 isoform 2 [Homo sapiens]
External Id: JHICC_RGS_Act_HTS
Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
Name: uHTS identification of small molecule activators of the adaptive arm of the Unfolded ...
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay
Name: Fluorescence polarization to screen for inhibitor that competite the binding of FadD2...
Source: Broad Institute
Target: FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE)
External Id: 2147-01_Inhibitor_SinglePoint_HTS_Activity
Name: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect...
Source: Broad Institute
Target: N/A
External Id: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity
Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
Name: Fluorescence polarization-based biochemical high throughput primary assay to identify...
Source: The Scripps Research Institute Molecular Screening Center
Target: RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens]
External Id: SIAE_INH_FP_1536_1X%INH PRUN
Name: Absorbance-based primary biochemical high throughput screening assay to identify acti...
Source: The Scripps Research Institute Molecular Screening Center
Target: caspase-3 preproprotein [Homo sapiens]
External Id: PROCASPASE3_ACT_EPIABS_1536_1X%ACT PRUN
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 Synonyms

4-Methoxy-5-hydroxycanthin-6-one
Nigakinone
4-methoxy-5-hydroxycantin-6-one
4-Methoxy-5-hydroxy-canthin-6-on
HMS2269C08
5-Hydroxy-4-methoxy-6H-indolo[3,2,1-de][1,5]naphthyridin-6-one
5-hydroxy-4-methoxycanthin-6-one
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