Hippuryl-His-Leu-OH
Modify Date: 2026-07-16 11:27:31
Hippuryl-His-Leu-OH structure
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Common Name | Hippuryl-His-Leu-OH | ||
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| CAS Number | 31373-65-6 | Molecular Weight | 429.47000 | |
| Density | 1.283 g/cm3 | Boiling Point | 912.4ºC at 760 mmHg | |
| Molecular Formula | C21H27N5O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 505.6ºC | |
Use of Hippuryl-His-Leu-OHHippuryl-His-Leu-OH is a substrate for detecting the activity of angiotensin I converting enzyme. The His-Leu released by Hippuryl-His-Leu-OH can react with o-phtbaldialdehyde or Fluorescamine (HY-D0715) for fluorescence detection[1][2][3]. |
Summary: Hippuryl-his-leu (Chinese name: 马脲酰组氨酰亮氨酸HHL) has a CAS number of 31373-65-6, molecular formula of C21H27N5O5, and molecular weight of 429.47000. This compound is a white to gray-white powder, with a boiling point of 912.4°C and should be stored at -20°C. For research-use only, not for medical or clinical usage.
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | hippuryl-his-leu |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Hippuryl-His-Leu-OH is a substrate for detecting the activity of angiotensin I converting enzyme. The His-Leu released by Hippuryl-His-Leu-OH can react with o-phtbaldialdehyde or Fluorescamine (HY-D0715) for fluorescence detection[1][2][3]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.283 g/cm3 |
|---|---|
| Boiling Point | 912.4ºC at 760 mmHg |
| Molecular Formula | C21H27N5O5 |
| Molecular Weight | 429.47000 |
| Flash Point | 505.6ºC |
| Exact Mass | 429.20100 |
| PSA | 153.28000 |
| LogP | 1.65520 |
| InChIKey | AAXWBCKQYLBQKY-IRXDYDNUSA-N |
| SMILES | CC(C)CC(NC(=O)C(Cc1cnc[nH]1)NC(=O)CNC(=O)c1ccccc1)C(=O)O |
| Storage condition | −20°C |
| Water Solubility | acetic acid: 50 mg/mL, clear, colorless |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
Synonym:None known Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
Risk Phrases: None Listed. Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. Ingestion: May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated. Inhalation: May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Deep freeze (below -20C). Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 31373-65-6: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Color: white Odor: None reported. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 150.00 - 155.00 deg C Autoignition Temperature: Not applicable. Flash Point: Not applicable. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C21H27N5O5.4H2O Molecular Weight: 501.50 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials, dust generation, excess heat, strong oxidants. Incompatibilities with Other Materials: Oxidizing agents. Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen. Hazardous Polymerization: Has not been reported. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 31373-65-6 unlisted. LD50/LC50: Not available. Carcinogenicity: Hippuryl-L-Histidyl-L-Leucine Tetrahydrate - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: S 24/25 Avoid contact with skin and eyes. S 28A After contact with skin, wash immediately with plenty of water. S 37 Wear suitable gloves. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). WGK (Water Danger/Protection) CAS# 31373-65-6: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 31373-65-6 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 31373-65-6 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A |
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| WGK Germany | 3 |
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This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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Hippuryl-His-Leu-OH CAS#:31373-65-6 |
| Literature: Chemical and Pharmaceutical Bulletin, , vol. 37, # 1 p. 145 - 147 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 2 | |
|---|---|
| DownStream 2 | |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Nα-(Benzoylglycyl)-L-His-L-Leu-OH |
| HIPPURYL-L-HISTIDYL-L-LEUCINE |
| BENZOYL-GLY-HIS-LEU |
| (S)-2-((S)-2-(2-Benzamidoacetamido)-3-(1H-imidazol-4-yl)propanamido)-4-methylpentanoic acid |
| hippuryl-L-histdyl-L-leucine |
| EINECS 250-597-9 |
| N-[N-(N-benzoylglycyl)-L-histidyl]-L-leucine |
| hippuryl-L-histidinyl-L-leucine |
| MFCD00149318 |
| Hippuryl-L-histidyl-L-leucine, free base(Synthetic) |
| HIPPURYL-HISTIDYL-LEUCINE |
| HIPPURYL-HIS-LEU //BP |
| Hippuryl-His-Leu-OH |Bz-Gly-His-Leu-OH |
| N-hippuryl-His-Leu |
| N-Benzoyl-Gly-L-His-L-Leu-OH |
| Bz-Gly-His-Leu |
| HIPPURYL-HIS-LEU |
| HIPPURYL-HIS-LEU-OH |
| Hippuryl-L-histidyl-L-leucine, tetrahydrate |
| hippuryl-L-histidyl-L-leucine |
| L-Leucine, N-benzoylglycyl-L-histidyl |
| BZ-GLY-HIS-LEU-OH |
| H-HIP-HIS-LEU-OH |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What are the downstream products of hippuryl-his-leu? |
| A: Related downstream products(CAS) of hippuryl-his-leu: 495-69-2;7763-65-7. |
| Q: What is the SMILES notation of hippuryl-his-leu? |
| A: SMILES notation of hippuryl-his-leu is CC(C)CC(NC(=O)C(Cc1cnc[nH]1)NC(=O)CNC(=O)c1ccccc1)C(=O)O. |
| Q: What are the storage conditions for hippuryl-his-leu? |
| A: Storage conditions for hippuryl-his-leu: −20°C. |
| Q: What are the upstream materials of hippuryl-his-leu? |
| A: Related upstream materials(CAS) of hippuryl-his-leu: 495-69-2;7763-65-7. |
| Q: What is the polar surface area (PSA) of hippuryl-his-leu? |
| A: Polar surface area (PSA) of hippuryl-his-leu is 153.28000. |
| Q: What are the uses of hippuryl-his-leu? |
| A: Main uses of hippuryl-his-leu: Hippuryl-His-Leu-OH is a substrate for detecting the activity of angiotensin I converting enzyme. The His-Leu released by Hippuryl-His-Leu-OH can react with o-phtbaldialdehyde or Fluorescamine (HY-D0715) for fluorescence detection[1][2][3]. |
| Q: What is the InChIKey of hippuryl-his-leu? |
| A: InChIKey of hippuryl-his-leu is AAXWBCKQYLBQKY-IRXDYDNUSA-N. |
| Q: What is the molecular weight of hippuryl-his-leu? |
| A: Molecular weight of hippuryl-his-leu is 429.47000. |
| Q: What is the CAS number of hippuryl-his-leu? |
| A: CAS number of hippuryl-his-leu is 31373-65-6. |
| Q: What is the boiling point of hippuryl-his-leu? |
| A: Boiling point of hippuryl-his-leu is 912.4ºC at 760 mmHg. |