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Liquid Crystalline Precursor Incorporating Chlorhexidine Acetate and Sliver Nanoparticles for Root Canal Disinfection
10.1039/C7BM00764G 2018-01-24 Lyotropic liquid crystal (LLC) has received increasing attention as a drug delivery system. However, LLC is not comprehensively demonstrated as an intra-canal disinfectant. In this study, a novel intra-canal disinfectant based on glycerol monooleate (GMO) LLC... |
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The Synthesis of Amphiphilic Polyethyleneimine/Calcium Phosphate Composites for Bispecific T-cell engager based Immunogene therapy
10.1039/C7BM01143A 2018-01-24 Bispecific T-cell engagers (BiTEs) are single chain variable fragment with specific structure, which could connect the surface antigen on cancer cells and CD3 ligand on T cells, and then engage T cells for cancer immunotherapy. In this report, a novel organic... |
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The Effect of Surface Charge on Oral Absorption of Polymeric Nanoparticles
10.1039/C7BM01096F 2018-01-22 Surface charge plays an important role in determining the interactions of nanoparticles with biological components. Substantial studies have demonstrated that surface charge affects the fate of nanoparticles after intravenous administration; however, few repo... |
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Fast Functionalization of Ultrasound Microbubbles Using Strain Promoted Click Chemistry
10.1039/C8BM00004B 2018-01-19 Functionalization on microbubbles (MBs) is a difficult issue due to their unstable nature. Here we report a fast and versatile method using strain promoted alkyne–azide cycloaddition (SPAAC) click reaction for microbubble functionalization. An azadibenzocyclo... |
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A pH- and temperature-responsive bioresorbable injectable hydrogel based on polypeptide block copolymer for the sustained delivery of proteins in vivo
10.1039/C7BM00980A 2018-01-19 Sustained delivery of protein therapeutics is limited owing to the fragile nature of protein. Despite great potential, delivery of proteins without loss of bioactivity remains challenging for use of protein therapeutics in clinics. To surmount this shortcomin... |
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Eumelanin–Fe3O4 hybrid nanoparticles for enhanced MR/PA imaging-assisted local photothermolysis
10.1039/C8BM00003D 2018-01-17 In this work, we report on biodegradable eumelanin–Fe3O4 hybrid nanoparticles (euMel–Fe3O4 NPs) for multiple imaging-assisted local photothermolysis. The euMel–Fe3O4 NPs are rationally prepared via a facile one-step co-precipitation method in the aqueous phas... |
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Nanocomposite injectable gels capable of self-replenishing regenerative extracellular microenvironments for in vivo tissue engineering
10.1039/C7BM01167A 2018-01-16 Injectable hydrogels are biomaterials that have the potential to provide scaffolds to cells for in situ tissue regeneration with a minimally invasive implantation procedure. The success of in vivo tissue engineering utilizing injectable gels depends on provid... |
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Dendritic phospholipid-based drug delivery systems
10.1039/C7BM01001J 2018-01-16 A class of new dendritic phospholipid compounds with different hydrophilic dendritic poly(L-lysine) peripheries from generations 1 (G1) to 3 (G3) (DPL-1 to DPL-3) were synthesised and nano-drug delivery systems based on these compounds were prepared (DPN-2 an... |
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Antimicrobial graphene materials: the interplay of complex materials characteristics and competing mechanisms
10.1039/C7BM00987A 2018-01-16 Graphene materials (GMs) exhibit attractive antimicrobial activities promising for biomedical and environmental applications. However, we still lack full control over their behaviour and performance mainly due to the complications arising from the coexistence... |
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Applying macromolecular crowding to 3D bioprinting: fabrication of 3D hierarchical porous collagen-based hydrogel constructs
10.1039/C7BM01015J 2018-01-16 Native tissues and/or organs possess complex hierarchical porous structures that confer highly-specific cellular functions. Despite advances in fabrication processes, it is still very challenging to emulate the hierarchical porous collagen architecture found ... |