Isovalerylcarnitine-d9 chloride

Modify Date: 2024-02-04 11:38:41

Isovalerylcarnitine-d9 chloride Structure
Isovalerylcarnitine-d9 chloride structure
Common Name Isovalerylcarnitine-d9 chloride
CAS Number 1334532-23-8 Molecular Weight 290.83
Density N/A Boiling Point N/A
Molecular Formula C12H15D9ClNO4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Isovalerylcarnitine-d9 chloride


Isovalerylcarnitine-d9 (chloride) is the deuterium labeled Isovalerylcarnitine (chloride)[1]. Isovalerylcarnitine chloride, a product of the catabolism of L-leucine, is a potent activator of the Ca2+-dependent proteinase (calpain) of human neutrophils[2].

 Names

Name Isovaleryl L-Carnitine-d9 Chloride
Synonym More Synonyms

 Isovalerylcarnitine-d9 chloride Biological Activity

Description Isovalerylcarnitine-d9 (chloride) is the deuterium labeled Isovalerylcarnitine (chloride)[1]. Isovalerylcarnitine chloride, a product of the catabolism of L-leucine, is a potent activator of the Ca2+-dependent proteinase (calpain) of human neutrophils[2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Pontremoli S, et al. Isovalerylcarnitine is a specific activator of calpain of human neutrophils. Biochem Biophys Res Commun. 1987 Nov 13;148(3):1189-95.  

 Chemical & Physical Properties

Molecular Formula C12H15D9ClNO4
Molecular Weight 290.83
Exact Mass 290.195862

 Synonyms

(2R)-3-Carboxy-N,N,N-trimethyl-2-(3-methyl-1-oxobutoxy)-1-propanaminium-d9 Chloride
(2R)-3-Carboxy-N,N,N-tris[(2H3)methyl]-2-[(3-methylbutanoyl)oxy]-1-propanaminium chloride
1-Propanaminium, 3-carboxy-N,N,N-tri(methyl-d3)-2-(3-methyl-1-oxobutoxy)-, chloride (1:1), (2R)-
1-Propanaminium, 3-carboxy-N,N,N-tri(methyl-d3)-2-(3-methyl-1-oxobutoxy)-, chloride, (2R)- (1:1)
(R)-3-Carboxy-N,N,N-trimethyl-2-(3-methyl-1-oxobutoxy)-1-propanaminium-d9 Chloride