Fibrinogen-Binding Peptide

Modify Date: 2024-01-02 10:48:38

Fibrinogen-Binding Peptide Structure
Fibrinogen-Binding Peptide structure
Common Name Fibrinogen-Binding Peptide
CAS Number 137235-80-4 Molecular Weight 565.62
Density 1.343 g/cm3 Boiling Point 1067.8ºC at 760 mmHg
Molecular Formula C25H39N7O8 Melting Point N/A
MSDS N/A Flash Point 599.6ºC

 Use of Fibrinogen-Binding Peptide


Fibrinogen-Binding Peptide (designed by anticomplementarity hypothesis) is a presumptive peptide mimic of the vitronectin binding site on the fibrinogen receptor. Fibrinogen-Binding Peptide binds fibrinogen and inhibits both the adhesion of platelets to fibrinogen and platelet aggregation, and also inhibits the adhesion of platelets to vitronectin[1].

 Names

Name (4S)-4-amino-5-[[(2S)-1-[[(2S,3S)-1-[(2S)-2-[[(1S)-1-carboxyethyl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxopentan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
Synonym More Synonyms

 Fibrinogen-Binding Peptide Biological Activity

Description Fibrinogen-Binding Peptide (designed by anticomplementarity hypothesis) is a presumptive peptide mimic of the vitronectin binding site on the fibrinogen receptor. Fibrinogen-Binding Peptide binds fibrinogen and inhibits both the adhesion of platelets to fibrinogen and platelet aggregation, and also inhibits the adhesion of platelets to vitronectin[1].
Related Catalog
References

[1]. Gartner TK, et al. The peptide Glu-His-Ile-Pro-Ala binds fibrinogen and inhibits platelet aggregation and adhesion to fibrinogen and vitronectin. Proc Soc Exp Biol Med. 1991 Oct;198(1):649-55.

 Chemical & Physical Properties

Density 1.343 g/cm3
Boiling Point 1067.8ºC at 760 mmHg
Molecular Formula C25H39N7O8
Molecular Weight 565.62
Flash Point 599.6ºC
Exact Mass 565.28600
PSA 236.91000
LogP 0.55120
Vapour Pressure 0mmHg at 25°C
Index of Refraction 1.577

 Synonyms

(4S)-4-amino-5-[[(2S)-1-[[(2S,3S)-1-[(2S)-2-[[(2S)-1-hydroxy-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxopentan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
Glutamyl-histidyl-isoleucyl-prolyl-alanine
Glu-his-ile-pro-ala