MS023 hydrochloride

Modify Date: 2024-04-12 02:01:49

MS023 hydrochloride structure	Common Name	MS023 hydrochloride
	CAS Number	2108631-19-0	Molecular Weight	396.78
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₂₈Cl₃N₃O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of MS023 hydrochloride

MS023 trihydrochloride is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC50s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively[1].

Name	MS023 (hydrochloride)

Description	MS023 trihydrochloride is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC50s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Methyltransferase
References	[1]. Eram MS, et al. A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases. ACS Chem Biol. 2016 Mar 18;11(3):772-81. [2]. Yinghui Zhu, et al. Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL-rearranged acute lymphoblastic leukemia. Blood. 2019 Oct 10;134(15):1257-1268.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> Histone Methyltransferase

References

[1]. Eram MS, et al. A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases. ACS Chem Biol. 2016 Mar 18;11(3):772-81.

[2]. Yinghui Zhu, et al. Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL-rearranged acute lymphoblastic leukemia. Blood. 2019 Oct 10;134(15):1257-1268.

Molecular Formula	C₁₇H₂₈Cl₃N₃O
Molecular Weight	396.78

MS023 hydrochloride

Use of MS023 hydrochloride

Names

MS023 hydrochloride Biological Activity

Chemical & Physical Properties