2108631-19-0

2108631-19-0 structure

Name: MS023 hydrochloride
Chemical Name: MS023 (hydrochloride)
CAS Number: 2108631-19-0
Molecular Formula: C₁₇H₂₈Cl₃N₃O
Molecular Weight: 396.78
Catalog: Signaling Pathways Epigenetics Histone Methyltransferase
Create Date: 2022-01-09 19:16:01
Modify Date: 2024-04-12 02:01:49
MS023 trihydrochloride is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC50s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively[1].

Name	MS023 (hydrochloride)

Description	MS023 trihydrochloride is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC50s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Methyltransferase
References	[1]. Eram MS, et al. A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases. ACS Chem Biol. 2016 Mar 18;11(3):772-81. [2]. Yinghui Zhu, et al. Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL-rearranged acute lymphoblastic leukemia. Blood. 2019 Oct 10;134(15):1257-1268.

Molecular Formula	C₁₇H₂₈Cl₃N₃O
Molecular Weight	396.78