RUNX-IN-2

Modify Date: 2024-01-04 23:40:08

RUNX-IN-2 Structure
RUNX-IN-2 structure
Common Name RUNX-IN-2
CAS Number 2893777-88-1 Molecular Weight 1524.52
Density N/A Boiling Point N/A
Molecular Formula C71H88Cl2N24O11 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of RUNX-IN-2


RUNX-IN-2 (Compound Conjugate 3) covalently binds to the RUNX-binding sequences, and inhibits the binding of RUNX proteins to their target sites. RUNX-IN-2 induces the p53-dependent apoptosis and inhibits cancer cell growth. RUNX-IN-2 inhibits tumor growth in PANC-1 xenograft mice. RUNX-IN-2 has high alkylation efficiency and specificity[1].

 Names

Name RUNX-IN-2

 RUNX-IN-2 Biological Activity

Description RUNX-IN-2 (Compound Conjugate 3) covalently binds to the RUNX-binding sequences, and inhibits the binding of RUNX proteins to their target sites. RUNX-IN-2 induces the p53-dependent apoptosis and inhibits cancer cell growth. RUNX-IN-2 inhibits tumor growth in PANC-1 xenograft mice. RUNX-IN-2 has high alkylation efficiency and specificity[1].
Related Catalog
Target

RUNX[1]

References

[1]. Hirose Y, et al. Anticancer Activities of DNA-Alkylating Pyrrole-Imidazole Polyamide Analogs Targeting RUNX Transcription Factors against p53-Mutated Pancreatic Cancer PANC-1 Cells. J Med Chem. 2023 Sep 14;66(17):12059-12068.  

 Chemical & Physical Properties

Molecular Formula C71H88Cl2N24O11
Molecular Weight 1524.52
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