RU28362

Modify Date: 2024-01-27 13:42:52

RU28362 structure	Common Name	RU28362
	CAS Number	74915-64-3	Molecular Weight	352.47
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₂₈O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of RU28362

RU28362 is a potent and selective glucocorticoid agonist. RU28362 increases the Bnip3 mRNA levels in neurons. RU28362 inhibits adrenocorticotrophic hormone (ACTH) and corticosterone secretion[1][2].

Name	ru 28362
Synonym	More Synonyms

Description	RU28362 is a potent and selective glucocorticoid agonist. RU28362 increases the Bnip3 mRNA levels in neurons. RU28362 inhibits adrenocorticotrophic hormone (ACTH) and corticosterone secretion[1][2].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor
References	[1]. Sandau US, et al. Glucocorticoids exacerbate hypoxia-induced expression of the pro-apoptotic gene Bnip3 in the developing cortex. Neuroscience. 2007 Jan 19;144(2):482-94. [2]. Ginsberg AB, et al. Specific and time-dependent effects of glucocorticoid receptor agonist RU28362 on stress-induced pro-opiomelanocortin hnRNA, c-fos mRNA and zif268 mRNA in the pituitary. J Neuroendocrinol. 2006 Feb;18(2):129-38.

Description

RU28362 is a potent and selective glucocorticoid agonist. RU28362 increases the Bnip3 mRNA levels in neurons. RU28362 inhibits adrenocorticotrophic hormone (ACTH) and corticosterone secretion[1][2].

Related Catalog

Research Areas >> Metabolic Disease

Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor

References

[1]. Sandau US, et al. Glucocorticoids exacerbate hypoxia-induced expression of the pro-apoptotic gene Bnip3 in the developing cortex. Neuroscience. 2007 Jan 19;144(2):482-94.

[2]. Ginsberg AB, et al. Specific and time-dependent effects of glucocorticoid receptor agonist RU28362 on stress-induced pro-opiomelanocortin hnRNA, c-fos mRNA and zif268 mRNA in the pituitary. J Neuroendocrinol. 2006 Feb;18(2):129-38.

Molecular Formula	C₂₃H₂₈O₃
Molecular Weight	352.47
Exact Mass	352.20400
PSA	57.53000
LogP	3.18560

11β,17β-dihydroxy-6,21-dimethyl-17α-pregna-1,4,6-trien-20-yn-3-one

RU28362

(11BETA,17BETA)-11,17-DIHYDROXY-6-METHYL-17-(1-PROPYNYL)-ANDROSTA-1,4,6-TRIEN-3-ONE

RU28362

Use of RU28362

Names

RU28362 Biological Activity

Chemical & Physical Properties

Synonyms