NNK-d3, 4-(Methyl-d3-nitrosoamino)-1-(3-pyridinyl)-1-butanone
Modify Date: 2024-01-11 11:56:59
NNK-d3, 4-(Methyl-d3-nitrosoamino)-1-(3-pyridinyl)-1-butanone structure
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Common Name | NNK-d3, 4-(Methyl-d3-nitrosoamino)-1-(3-pyridinyl)-1-butanone | ||
|---|---|---|---|---|
| CAS Number | 86270-92-0 | Molecular Weight | 210.24800 | |
| Density | 1.17g/cm3 | Boiling Point | 423.9ºC at 760 mmHg | |
| Molecular Formula | C10H10D3N3O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 210.2ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of NNK-d3, 4-(Methyl-d3-nitrosoamino)-1-(3-pyridinyl)-1-butanoneNNK-d3 is the deuterium labeled NNK (HY-126477)[1][2]. |
| Name | N-(4-oxo-4-pyridin-3-ylbutyl)-N-(trideuteriomethyl)nitrous amide |
|---|---|
| Synonym | More Synonyms |
| Description | NNK-d3 is the deuterium labeled NNK (HY-126477)[1][2]. |
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| Related Catalog | |
| In Vitro | 氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。 NNK (100 pM；0-60 分钟) 刺激 PKCα 和 MAPKs ERK1/2 的激活，直接诱导 c-Myc 磷酸化[2]。 NNK (100 pM；96 小时) 增强 WT 细胞增殖，但不影响表达 AA 的 c-Myc 突变体[2]。 |
| References |
| Density | 1.17g/cm3 |
|---|---|
| Boiling Point | 423.9ºC at 760 mmHg |
| Molecular Formula | C10H10D3N3O2 |
| Molecular Weight | 210.24800 |
| Flash Point | 210.2ºC |
| Exact Mass | 210.12000 |
| PSA | 62.63000 |
| LogP | 1.65770 |
| Index of Refraction | 1.557 |
| NNK-d3 |