Sarcosine

Names

[ CAS No. ]:
107-97-1

[ Name ]:
Sarcosine

[Synonym ]:
Acide (méthylamino)acétique
SAR
Glycine, N-methyl-
sarcosine zwitterion
MeNHCH2CO2H
MeHNCH2CO2H
EINECS 203-538-6
Methylaminoethanoic acid
N-methyl-Glycine
N-methylaminoacetic acid
Sarcosine
N-Methylglycocoll
N-Methylglycine
Methylaminoacetic Acid
MFCD00004279
(methylamino)-Acetic acid
H-Sar-OH

Biological Activity

[Description]:

Sarcosine is a glycine transporter type 1 (GlyT) inhibitor and an N-methyl-D-aspartate (NMDA) receptor co-agonist at the glycine binding site.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GlyT

Signaling Pathways >> Neuronal Signaling >> GlyT

Natural Products >> Acids and Aldehydes

Research Areas >> Others

[Target]

Human Endogenous Metabolite

[References]

[1]. Zhang HX, et al. The glycine transport inhibitor sarcosine is an NMDA receptor co-agonist that differs from glycine. J Physiol. 2009 Jul 1;587(Pt 13):3207-20.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
195.1±23.0 °C at 760 mmHg

[ Melting Point ]:
208-212 °C (dec.)(lit.)

[ Molecular Formula ]:
C₃H₇NO₂

[ Molecular Weight ]:
89.093

[ Flash Point ]:
71.8±22.6 °C

[ Exact Mass ]:
89.047676

[ PSA ]:
49.33000

[ LogP ]:
-0.79

[ Vapour Pressure ]:
0.2±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.431

[ Storage condition ]:
Store at RT.

[ Water Solubility ]:
1480 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VQ2897000

CHEMICAL NAME :: Sarcosine

CAS REGISTRY NUMBER :: 107-97-1

BEILSTEIN REFERENCE NO. :: 1699442

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C3-H7-N-O2

MOLECULAR WEIGHT :: 89.11

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

[ RTECS ]:
VQ2897000

[ HS Code ]:
29224995

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

Long-term application of glycine transporter inhibitors acts antineuropathic and modulates spinal N-methyl-D-aspartate receptor subunit NR-1 expression in rats.

Anesthesiology 121(1) , 160-9, (2014)

Dysfunction of spinal glycinergic neurotransmission is a major pathogenetic factor in neuropathic pain. The synaptic glycine concentration is controlled by the two glycine transporters (GlyT) 1 and 2....

Development of High-purity Certified Reference Materials for 17 Proteinogenic Amino Acids by Traceable Titration Methods.

Anal. Sci. 31 , 805-14, (2015)

To ensure the reliability of amino acid analyses, the National Metrology Institute of Japan of the National Institute of Advanced Industrial Science and Technology (NMIJ/AIST) has developed high-purit...

[Membrane-bound proteases of ompT+ and ompT- Vibrio cholerae strains].

Zh. Mikrobiol. Epidemiol. Immunobiol. (2) , 3-12, (2013)

Detection ofproteases in outer membranes (OM) of ompT+ and ompT- Vibrio cholerae strains of O1 and O139 serogroups.Specific sterile preparations of OM were obtained by lysis of live V. cholerae cells ...

Related Compounds

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