LUMICHROME

Names

[ Name ]:
LUMICHROME

[Synonym ]:
MFCD00005021
7,8-Dimethylalloxazine
LUM
flavins
7,8-dimethyl-1H-benzo[g]pteridine-2,4-dione
6,7-DIMETHYLALLOXAZINE
EINECS 214-120-8
Benzo[g]pteridine-2,4(1H,3H)-dione,7,8-dimethyl
7,8-dimethyl-benzo[g]pteridine-2,4(1H,3H)-dione

Biological Activity

[Description]:

Lumichrome, a photodegradation product of Riboflavin, is an endogenous compound in humans. Lumichrome inhibits human lung cancer cell growth and induces apoptosis via a p53-dependent mechanism[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[Target]

Human Endogenous Metabolite

[References]

[1]. Bergh VJ, et al. Influence of formulation on photoinactivation of bacteria by lumichrome. Pharmazie. 2015;70(9):574-580.

[2]. Chantarawong W, et al. Lumichrome Inhibits Human Lung Cancer Cell Growth and Induces Apoptosis via a p53-Dependent Mechanism. Nutr Cancer. 2019;71(8):1390-1402.

Chemical & Physical Properties

[ Density]:
1.388g/cm3

[ Melting Point ]:
300 °C

[ Molecular Formula ]:
C₁₂H₁₀N₄O₂

[ Molecular Weight ]:
242.23300

[ Exact Mass ]:
242.08000

[ PSA ]:
91.50000

[ LogP ]:
0.77640

[ Index of Refraction ]:
1.66

[ Stability ]:
Stable. Incompatible with strong oxidizing agents. Combustible.

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Enhanced Indirect Photochemical Transformation of Histidine and Histamine through Association with Chromophoric Dissolved Organic Matter.

Environ. Sci. Technol. 49 , 5511-9, (2015)

Photochemical transformations greatly affect the stability and fate of amino acids (AAs) in sunlit aquatic ecosystems. Whereas the direct phototransformation of dissolved AAs is well investigated, the...

The B vitamins nicotinamide (B3) and riboflavin (B2) stimulate metamorphosis in larvae of the deposit-feeding polychaete Capitella teleta: implications for a sensory ligand-gated ion channel.

PLoS ONE 9(11) , e109535, (2014)

Marine sediments can contain B vitamins, presumably incorporated from settled, decaying phytoplankton and microorganisms associated with decomposition. Because B vitamins may be advantageous for the e...

Molecular and functional characterization of riboflavin specific transport system in rat brain capillary endothelial cells.

Brain Res. 1468 , 1-10, (2012)

Riboflavin is an important water soluble vitamin (B2) required for metabolic reactions, normal cellular growth, differentiation and function. Mammalian brain cells cannot synthesize riboflavin and mus...

Related Compounds

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