CNQX

Names

[ Name ]:
CNQX

[Synonym ]:
CNQX disodium salt hydrate
CNQX 2NA
6-Nitro-7-cyanoquinoxaline-2,3-dione
MFCD00069232
6-Cyano-7-nitroquinoxaline-2,3-dione FG-9065
7-Nitro-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carbonitrile
2,3-Dihydroxy-7-nitroquinoxaline-6-carbonitrile
7-Nitro-2,3-dioxo-1,2,3,4-tetrahydro-6-quinoxalinecarbonitrile
CNQX DISODIUM
CNOX
CNQX DISODIUM SALT
CNQX
6-Quinoxalinecarbonitrile, 1,2,3,4-tetrahydro-7-nitro-2,3-dioxo-
6-Cyano-7-nitroquinoxaline-2,3-dione disodium salt hydrate
FG-9065
CNQX DISODIUM KAINATE/AMPA RECEPTOR

Biological Activity

[Description]:

CNQX (FG9065) is a potent AMPA/kainate receptor antagonist.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Neurological Disease

[In Vitro]

In rat hippocampal slices bathed in Mg2+-free medium, 10 μM CNQX reversibly blocks responses to a-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA), quisqualate and kainate but not NMDA[1]. Superfusion of hippocampal slices with 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition[2]. CNQX (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments[3]. CNQX-mediated depolarizations are mediated by AMPAR but not kainate receptors in TRN neurons[4].

[In Vivo]

The bilateral infusion of CNQX (0.5 or 1.25 μg) into the amygdala or dorsal hippocampus 10 min prior to a retention test partially blocks the expression of stepdown inhibitory avoidance in rats 24 h after training. CNQX causes a complete blockade at a dose of 0.5 μg[5].

[Cell Assay]

CNQX is applied by injecting a bolus into the input line of the chamber over 60 s using a motorized syringe pump. In a subpopulation of neurons, CNQX is bath applied for 5 min. Control injections of physiological saline or vehicle (DMSO) does not alter membrane potential/input resistance during voltage recordings[4].

[References]

[1]. Blake JF, et al. CNQX blocks acidic amino acid induced depolarizations and synaptic components mediated by non-NMDA receptors in rathippocampal slices. Neurosci Lett. 1988 Jun 29;89(2):182-6.

[2]. Neuman RS, et al. Blockade of excitatory synaptic transmission by 6-cyano-7-nitroquinoxaline-2,3-dione(CNQX) in the hippocampus in vitro. Neurosci Lett. 1988 Sep 23;92(1):64-8.

[3]. Alford S, et al. CNQX and DNQX block non-NMDA synaptic transmission but not NMDA-evoked locomotion in lamprey spinal cord. Brain Res. 1990 Jan 8;506(2):297-302.

[4]. Lee SH, et al. Selective excitatory actions of DNQX and CNQX in rat thalamic neurons. J Neurophysiol. 2010 Apr;103(4):1728-34.

[5]. Kim M, et al. Infusion of the non-NMDA receptor antagonist CNQX into the amygdala blocks the expression of fear-potentiated startle. Behav Neural Biol. 1993 Jan;59(1):5-8.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
659.3ºC at 760 mmHg

[ Melting Point ]:
300 °C

[ Molecular Formula ]:
C₉H₄N₄O₄

[ Molecular Weight ]:
232.152

[ Flash Point ]:
352.6ºC

[ Exact Mass ]:
232.023254

[ PSA ]:
135.33000

[ LogP ]:
0.64

[ Vapour Pressure ]:
0.001mmHg at 25°C

[ Index of Refraction ]:
1.699

[ Storage condition ]:
Desiccate at RT

[ Stability ]:
Store Tightly Sealed at RT

[ Water Solubility ]:
H2O: 10 mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

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Related Compounds

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