5-Chloro-8-hydroxyquinoline
Names
[ CAS No. ]:
130-16-5
[ Name ]:
5-Chloro-8-hydroxyquinoline
[Synonym ]:
5-Chloro-8-hydroxy quinoline
5-chloroquinolin-8-ol
5-Chloroquinophenol
cloxiquine
5-Chlorooxine
EINECS 204-978-1
5-Chloro-8-quinolinol
5-Chloro-8-hydroxyquinoline
5-Chloro-quinolin-8-ol
8-Quinolinol, 5-chloro-
Dermofungin
quinolin-8-ol, 5-chloro-
5-Chloro-8-oxyquinoline
MFCD00006788
5-Chloro-8-oxychinolin
cloxyquin
5-CHLORO-8-HYDROXY-QUINOLINE
Biological Activity
[Description]:
[Related Catalog]:
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Boiling Point ]:
348.7±22.0 °C at 760 mmHg
[ Melting Point ]:
122-124 °C(lit.)
[ Molecular Formula ]:
C9H6ClNO
[ Molecular Weight ]:
179.603
[ Flash Point ]:
164.7±22.3 °C
[ Exact Mass ]:
179.013794
[ PSA ]:
33.12000
[ LogP ]:
3.02
[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C
[ Index of Refraction ]:
1.697
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- VC4590000
- CHEMICAL NAME :
- 8-Quinolinol, 5-chloro-
- CAS REGISTRY NUMBER :
- 130-16-5
- BEILSTEIN REFERENCE NO. :
- 0005289
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C9-H6-Cl-N-O
- MOLECULAR WEIGHT :
- 179.61
- WISWESSER LINE NOTATION :
- T66 BNJ GG JQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 1200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Bacteria - Escherichia coli
- DOSE/DURATION :
- 1 mmol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 307,141,1994
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi:Irritant
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S36-S24/25
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
VC4590000
[ HS Code ]:
2933499090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933499090
[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
J. Med. Chem. 54 , 591-602, (2011)
Fragment-based lead design (FBLD) has been used to identify new metal-binding groups for metalloenzyme inhibitors. When screened at 1 mM, a chelator fragment library (CFL-1.1) of 96 compounds produced...
Photoluminescence and thermoanalytical studies of complexes based on 5-Cl-8-hydroxyquinoline and calix[4]arene ligands.Mater. Sci. Eng. C. Mater. Biol. Appl. 33(4) , 2213-20, (2013)
A innovative 5-Cl-8-oxyquinolinepropoxycalix[4]arene ligand (2) have been prepared, exhibiting, at room temperature, blue fluorescent light emission and resulting in shift band to green fluorescent li...
Poly(L-lactide) and poly(butylene succinate) immiscible blends: from electrospinning to biologically active materials.Mater. Sci. Eng. C. Mater. Biol. Appl. 41 , 119-26, (2014)
For the first time the preparation of defect-free fibers from immiscible blends of high molar mass poly(lactic acid) (PLA) and poly(butylene succinate) (PBS) in the whole range of the polyester weight...