Pheniramine maleate
Names
[ CAS No. ]:
132-20-7
[ Name ]:
Pheniramine maleate
[Synonym ]:
(2Z)-But-2-endisäure--N,N-dimethyl-3-phenyl-3-pyridin-2-ylpropan-1-amin(1:1)
Pheniramine maleate
1-(N,N-Dimethylamino)-3-(phenyl-3-a-pyridyl)propane Maleate
N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine (2Z)-but-2-enedioate (1:1)
EINECS 205-051-4
3-Phenyl-3-(2-pyridyl)-N,N-dimethylpropylamine Maleate
N,N-dimethyl-3-phenyl-3-pyridin-2-ylpropan-1-amine (2Z)-but-2-enedioate
(Z)-but-2-enedioic acid,N,N-dimethyl-3-phenyl-3-pyridin-2-ylpropan-1-amine
Pheniramine maleate salt
2-Pyridinepropanamine, N,N-dimethyl-γ-phenyl-, (2Z)-2-butenedioate (1:1)
N,N-Dimethyl-3-phenyl-3-(2-pyridinyl)-1-propanamine (2Z)-2-butenedioate (1:1)
acide (2Z)-but-2-ènedioïque - N,N-diméthyl-3-phényl-3-pyridin-2-ylpropan-1-amine (1:1)
UNII:NYW905655B
Naphcon A
MFCD00079250
Biological Activity
[Description]:
[Related Catalog]:
[Related Small Molecules]
Chemical & Physical Properties
[ Boiling Point ]:
348.3ºC at 760 mmHg
[ Melting Point ]:
104-108°C
[ Molecular Formula ]:
C20H24N2O4
[ Molecular Weight ]:
356.416
[ Flash Point ]:
164.5ºC
[ Exact Mass ]:
356.173615
[ PSA ]:
90.73000
[ LogP ]:
2.87700
[ Vapour Pressure ]:
5.07E-05mmHg at 25°C
[ Stability ]:
Stable. Incompatible with strong oxidizing agents.
[ Water Solubility ]:
>=1 g/100 mL at 24 ºC
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UT0175000
- CAS REGISTRY NUMBER :
- 132-20-7
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 11
- MOLECULAR FORMULA :
- C16-H20-N2.C4-H4-O4
- MOLECULAR WEIGHT :
- 356.46
- WISWESSER LINE NOTATION :
- T6NJ BYR&2N1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - child
- DOSE/DURATION :
- 30 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - antipsychotic Lungs, Thorax, or Respiration - cyanosis
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 520 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - changes in motor activity (specific assay) Behavioral - aggression
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 268 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - changes in motor activity (specific assay) Behavioral - aggression
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 111 mg/kg
- TOXIC EFFECTS :
- Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - respiratory stimulation
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 270 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 72 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 1120 ug/kg
- REFERENCE :
- IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 19,516,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83158 No. of Facilities: 1580 (estimated) No. of Industries: 3 No. of Occupations: 9 No. of Employees: 6126 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83158 No. of Facilities: 12 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 494 (estimated) No. of Female Employees: 206 (estimated)
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302
[ Precautionary Statements ]:
P301 + P312 + P330
[ Hazard Codes ]:
Xn: Harmful;
[ Risk Phrases ]:
R22
[ Safety Phrases ]:
S36
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
UT0175000
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