Benzenecarboximidamide hydrochloride hydrate

Names

[ CAS No. ]:
206752-36-5

[ Name ]:
Benzenecarboximidamide hydrochloride hydrate

[Synonym ]:
EINECS 216-795-4
Benzenecarboximidamide hydrochloride hydrate
Benzamidine HCl Hydrate
MFCD00066285
Benzenecarboximidamide, hydrochloride, hydrate (1:1:1)
AMIDINOBENZENE HYDROCHLORIDE
Benzamidine hydrochloride, hydrate
Benzamidine hydrochloride hydrate
Benzamidine Hydrochloride Monohydrate
Benzamidinium chloride

Biological Activity

[Description]:

Benzenecarboximidamide, hydrochloride, hydrate (1:1:x) (Benzamidine hydrochloride hydrate) is a reversible competitive trypsin-like serine proteases inhibitor with Kis of 20, 21, 97, 110, 320 and 750 μM against Tryptase, Trypsin, uPA, Factor Xa, Thrombin and tPA, respectively[1][2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease

Research Areas >> Cancer

[Target]

Ki: 20 μM (Tryptase), 21 μM (Trypsin), 97 μM (uPA), 110 μM (Factor Xa), 320 μM (Thrombin), 750 μM (tPA)[1]

[References]

[1]. Katz BA, et al. Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator. Chem Biol. 2000 Apr;7(4):299-312.

[2]. Tanizawa K, et al. Proteolytic enzymes. VI. Aromatic amidines as competitive inhibitors of trypsin. J Biochem. 1971 May;69(5):893-9.

Chemical & Physical Properties

[ Boiling Point ]:
208.5ºC at 760mmHg

[ Melting Point ]:
86-88 °C(lit.)

[ Molecular Formula ]:
C₇H₈N_2.ClH_.xH₂O

[ Molecular Weight ]:
174.628

[ Flash Point ]:
79.9ºC

[ Exact Mass ]:
174.055984

[ PSA ]:
59.10000

[ LogP ]:
2.50840

[ Vapour Pressure ]:
0.213mmHg at 25°C

[ Storage condition ]:
0-6°C

[ Water Solubility ]:
soluble

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
CV6260000

Articles

Preparation of extracts from yeast.

Meth. Enzymol. 182 , 154, (1990)

Thermodynamics of the interaction between oxytocin and its myometrial receptor in sheep: a stepwise binding mechanism.

Biochem. Pharmacol. 91(1) , 119-27, (2014)

Entropy (ΔS), enthalpy (ΔH) and heat capacity (ΔCp) changes attending the oxytocin interaction with its two binding sites on myometrial cell membranes in sheep were derived from the temperature depend...

Synthesis and characterization of a lubricin mimic (mLub) to reduce friction and adhesion on the articular cartilage surface.

Biomaterials 73 , 42-50, (2015)

The lubricating proteoglycan, lubricin, facilitates the remarkable low friction and wear properties of articular cartilage in the synovial joints of the body. Lubricin lines the joint surfaces and pla...

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.