6-Biopterin
Names
[ CAS No. ]:
22150-76-1
[ Name ]:
6-Biopterin
[Synonym ]:
D-erythro-Biopterin
2-Amino-6-[(1R,2S)-1,2-dihydroxypropyl]-4(1H)-pteridinone
4(1H)-Pteridinone, 2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-
2-Amino-6-[(1R,2S)-1,2-dihydroxypropyl]pteridin-4(8H)-one
biopterin
MFCD00036787
1,2-Propanediol, 1-(1,2-dihydro-4-hydroxy-2-imino-6-pteridinyl)-, (1R,2S)-
L-Biopterin
Pterin HB2
pterinhb2
(-)-Biopterin
L-Erythro-Biopterin
6-BIOPTERIN
EINECS 244-807-8
(1R,2S)-1-(4-Hydroxy-2-imino-1,2-dihydro-6-pteridinyl)-1,2-propanediol
[S-(R*,S*)]-2-Amino-6-(1,2-dihydroxypropyl)-4(1H)-pteridinone
(1'S,2'R)-Biopterin
Pterin H B2
Biological Activity
[Description]:
[Related Catalog]:
[Target]
Human Endogenous Metabolite
[In Vitro]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.9±0.1 g/cm3
[ Boiling Point ]:
563.4±60.0 °C at 760 mmHg
[ Melting Point ]:
>210°C dec.
[ Molecular Formula ]:
C9H11N5O3
[ Molecular Weight ]:
237.215
[ Flash Point ]:
294.5±32.9 °C
[ Exact Mass ]:
237.086182
[ PSA ]:
138.01000
[ LogP ]:
-3.84
[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C
[ Index of Refraction ]:
1.822
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UO3506000
- CHEMICAL NAME :
- 4(3H)-Pteridinone, 2-amino-6-(L-erythro-1,2-dihydroxypropyl)-
- CAS REGISTRY NUMBER :
- 22150-76-1
- LAST UPDATED :
- 199509
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C9-H11-N5-O3
- MOLECULAR WEIGHT :
- 237.25
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >3 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 879 mg/kg
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in bladder weight Endocrine - changes in spleen weight
MUTATION DATA
- TEST SYSTEM :
- Insect - Drosophila melanogaster
- DOSE/DURATION :
- 10 ug/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 128,147,1984
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi:Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S36
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
UO3506000
[ HS Code ]:
2933990090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Am. J. Physiol. Heart Circ. Physiol. 307(11) , H1559-64, (2014)
Rupture of abdominal aortic aneurysm (AAA) is unpredictable and lethal. A clinically valid biomarker to monitor the disease has not been available. Based on our recent discoveries that uncoupled endot...
Phenylalanine hydroxylase: function, structure, and regulation.IUBMB Life 65(4) , 341-9, (2013)
Mammalian phenylalanine hydroxylase (PAH) catalyzes the rate-limiting step in the phenylalanine catabolism, consuming about 75% of the phenylalanine input from the diet and protein catabolism under ph...
Communication between the zinc and tetrahydrobiopterin binding sites in nitric oxide synthase.Biochemistry 53(25) , 4216-23, (2014)
The nitric oxide synthase (NOS) dimer is stabilized by a Zn(2+) ion coordinated to four symmetry-related Cys residues exactly along the dimer 2-fold axis. Each of the two essential tetrahydrobiopterin...