4-Trifluoromethylphenol
Names
[ CAS No. ]:
402-45-9
[ Name ]:
4-Trifluoromethylphenol
[Synonym ]:
4-Trifluoromethylphenol
4-(Trifluormethyl)benzolol
P-Trifluoromethylphenol
4-(Trifluoromethyl)phenol
α,α,α-Trifluoro-p-cresol
Phenol, 4-(trifluoromethyl)-
4-Hydroxybenzotrifluoride
4-(Trifluoromethyl)-phenol
4-Hydroxy-α,α,α-trifluorotoluene
MFCD00002363
alpha,alpha,alpha-Trifluoro-p-cresol
EINECS 206-945-7
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
185.5±35.0 °C at 760 mmHg
[ Melting Point ]:
45-47 °C(lit.)
[ Molecular Formula ]:
C7H5F3O
[ Molecular Weight ]:
162.109
[ Flash Point ]:
80.1±20.4 °C
[ Exact Mass ]:
162.029251
[ PSA ]:
20.23000
[ LogP ]:
2.82
[ Vapour Pressure ]:
0.5±0.4 mmHg at 25°C
[ Index of Refraction ]:
1.458
[ Storage condition ]:
0-6°C
MSDS
Safety Information
[ Symbol ]:
GHS02, GHS05, GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H228-H301-H315-H318-H335
[ Precautionary Statements ]:
P210-P261-P280-P301 + P310-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ Hazard Codes ]:
Xi:Irritant
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S39-S24/25
[ RIDADR ]:
UN 2926 4.1/PG 2
[ WGK Germany ]:
3
[ HS Code ]:
2907299090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2908199090
[ Summary ]:
HS: 2908199090. derivatives of polyphenols or phenol-alcohols containing only halogen substituents and their salts. VAT:17.0%. tax rebate rate:9.0%. supervision conditions:None. MFN tariff:5.5%. general tariff:30.0%
Articles
Chem. Commun. (Camb.) (39) , 4780-2, (2008)
A high yielding, batch mode synthesis of diaryl ethers and sulfides by an S(N)Ar fluoride-mediated process in scCO(2) has been developed; the use of a polymer-supported imidazolium fluoride reagent in...
Structural analysis of flavinylation in vanillyl-alcohol oxidase.J. Biol. Chem. 275(49) , 38654-8, (2000)
Vanillyl-alcohol oxidase (VAO) is member of a newly recognized flavoprotein family of structurally related oxidoreductases. The enzyme contains a covalently linked FAD cofactor. To study the mechanism...
Simultaneous determination of fluoxetine and its metabolite p-trifluoromethylphenol in human liver microsomes using a gas chromatographic-electron-capture detection procedure.J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 769(2) , 305-11, (2002)
An gas chromatography-electron-capture detection method has been developed for simultaneous determination of fluoxetine and p-trifluoromethylphenol (TFMP), an O-dealkylated metabolite of fluoxetine in...