4-Trifluoromethylphenol
4-Trifluoromethylphenol structure
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Common Name | 4-Trifluoromethylphenol | ||
|---|---|---|---|---|
| CAS Number | 402-45-9 | Molecular Weight | 162.109 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 185.5±35.0 °C at 760 mmHg | |
| Molecular Formula | C7H5F3O | Melting Point | 45-47 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 80.1±20.4 °C | |
| Symbol |
GHS02, GHS05, GHS06 |
Signal Word | Danger | |
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Diaryl ether synthesis in supercritical carbon dioxide in batch and continuous flow modes.
Chem. Commun. (Camb.) (39) , 4780-2, (2008) A high yielding, batch mode synthesis of diaryl ethers and sulfides by an S(N)Ar fluoride-mediated process in scCO(2) has been developed; the use of a polymer-supported imidazolium fluoride reagent in batch mode led to the development of a fixed-bed continuou... |
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Structural analysis of flavinylation in vanillyl-alcohol oxidase.
J. Biol. Chem. 275(49) , 38654-8, (2000) Vanillyl-alcohol oxidase (VAO) is member of a newly recognized flavoprotein family of structurally related oxidoreductases. The enzyme contains a covalently linked FAD cofactor. To study the mechanism of flavinylation we have created a design point mutation (... |
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Simultaneous determination of fluoxetine and its metabolite p-trifluoromethylphenol in human liver microsomes using a gas chromatographic-electron-capture detection procedure.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 769(2) , 305-11, (2002) An gas chromatography-electron-capture detection method has been developed for simultaneous determination of fluoxetine and p-trifluoromethylphenol (TFMP), an O-dealkylated metabolite of fluoxetine in human liver microsomes. Prior to the analysis, aliquots of... |
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Chemical characteristics for optimizing CYP2E1 inhibition.
Chem. Biol. Interact. 242 , 139-44, (2015) Cytochrome P450 2E1 (CYP2E1) expression and activity in the liver is associated with the degree of liver damage in patients with alcoholic steatohepatitis (ASH) as well as non-alcoholic steatohepatitis (NASH). CYP2E1 is known to generate reactive oxygen speci... |
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Determination of p-trifluoromethylphenol, a metabolite of fluoxetine, in tissues and body fluids using an electron-capture gas chromatographic procedure.
J. Chromatogr. B. Biomed. Sci. Appl. 698(1-2) , 103-9, (1997) An electron-capture gas chromatographic procedure was developed for the analysis of p-trifluoromethylphenol, an O-dealkylated metabolite of fluoxetine, in biological samples. A basic extraction of the biological sample was employed, followed by derivatization... |
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Spontaneous hydrolysis of 4-trifluoromethylphenol to a quinone methide and subsequent protein alkylation.
Chem. Biol. Interact. 126(1) , 1-14, (2000) 4-Trifluoromethylphenol (4-TFMP) was cytotoxic to precision-cut rat liver slices as indicated by loss of intracellular potassium. Intracellular glutathione levels decreased and fluoride ion levels increased in a time and concentration-dependent manner. The cy... |
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Bacillus anthracis o-succinylbenzoyl-CoA synthetase: reaction kinetics and a novel inhibitor mimicking its reaction intermediate.
Biochemistry 47(47) , 12434-47, (2008) o-Succinylbenzoyl-CoA (OSB-CoA) synthetase (EC 6.2.1.26) catalyzes the ATP-dependent condensation of o-succinylbenzoate (OSB) and CoA to form OSB-CoA, the fourth step of the menaquinone biosynthetic pathway in Bacillus anthracis. Gene knockout studies have hi... |