Nalmefene

Names

[ Name ]:
Nalmefene

[Synonym ]:
Arthene
Nalmefenum
Nalmetrenum
Alcofene
Nalmetreno
6-desoxy-6-methylenenaltrexone
Nalmetrene
Revex
nalmefene
Cervene

Biological Activity

[Description]:

Nalmefene is a long acting opioid (MOR and DOR antagonist), and a partial KOR agonist. Nalmefene is used for opioid overdose and alcohol dependence[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor

Signaling Pathways >> Neuronal Signaling >> Opioid Receptor

Research Areas >> Neurological Disease

[Target]

MOR, DOR, KOR[1]

[References]

[1]. Wang DS, et al. Nalmefene: a long-acting opioid antagonist. Clinical applications in emergency medicine. J Emerg Med. 1998 May-Jun;16(3):471-5.

[2]. Mann K, et al. Nalmefene for the management of alcohol dependence: review on its pharmacology, mechanism of action and meta-analysis on its clinical efficacy. Eur Neuropsychopharmacol. 2016 Dec;26(12):1941-1949.

Chemical & Physical Properties

[ Melting Point ]:
188 - 190ºC

[ Molecular Formula ]:
C₂₁H₂₅NO₃

[ Molecular Weight ]:
339.43

[ Exact Mass ]:
339.18300

[ PSA ]:
52.93000

[ LogP ]:
2.45040

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Treatment of alcohol dependence: recent progress and reduction of consumption.

Minerva Med. 105(6) , 447-66, (2014)

Alcohol dependence (AD) is a major public health problem. Currently, three drugs for the treatment of AD have been approved by both the European Medicines Agency (EMA) and the Food and Drug Administra...

Pharmacotherapy for adults with alcohol use disorders in outpatient settings: a systematic review and meta-analysis.

JAMA 311(18) , 1889-900, (2014)

Alcohol use disorders cause substantial morbidity and early mortality yet remain greatly undertreated. Medications are considerably underused.To conduct a systematic review and meta-analysis of the be...

In vivo characterization of the opioid antagonist nalmefene in mice.

Life Sci. 86(15-16) , 624-30, (2010)

The current study assessed the in vivo antagonist properties of nalmefene using procedures previously used to characterize the opioid antagonists naloxone, naltrexone, 6beta-naltrexol and nalbuphine.I...

Related Compounds

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