alpha-Tocopherol acetate
Names
[ CAS No. ]:
58-95-7
[ Name ]:
alpha-Tocopherol acetate
[Synonym ]:
(2R)-2,5,7,8-Tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromen-6-yl acetate
a-Tocopheryl Acetate
Vitamin E acetate
[2R*(4R*,8R*)]-3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol Acetate
EINECS 231-710-0
Eprolin
Tocopheryl acetate
E-Vimin
Evion
MFCD00072052
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-, acetate, (2R)-
Vitamin- E acetate
D-α-Tocopheryl acetate
a-Tocopherol Acetate
TOCOPHEROL ACETATE
Biological Activity
[Description]:
[Related Catalog]:
[References]
Chemical & Physical Properties
[ Density]:
0.9±0.1 g/cm3
[ Boiling Point ]:
184 ºC
[ Melting Point ]:
28 ºC
[ Molecular Formula ]:
C31H52O3
[ Molecular Weight ]:
472.743
[ Flash Point ]:
235.6±24.7 °C
[ Exact Mass ]:
472.391632
[ PSA ]:
35.53000
[ LogP ]:
12.07
[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C
[ Index of Refraction ]:
1.488
[ Water Solubility ]:
<0.1 g/100 mL at 17 ºC
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GP8280000
- CHEMICAL NAME :
- 6-Chromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, (+)-
- CAS REGISTRY NUMBER :
- 58-95-7
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C31-H52-O3
- MOLECULAR WEIGHT :
- 472.83
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 182 gm/kg/13W-C
- TOXIC EFFECTS :
- Liver - changes in liver weight Blood - pigmented or nucleated red blood cells Blood - changes in other cell count (unspecified)
- REFERENCE :
- FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 24,1043,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80575 No. of Facilities: 149 (estimated) No. of Industries: 3 No. of Occupations: 9 No. of Employees: 8005 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80575 No. of Facilities: 834 (estimated) No. of Industries: 5 No. of Occupations: 9 No. of Employees: 8113 (estimated) No. of Female Employees: 5676 (estimated)
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves
[ Safety Phrases ]:
S24/25
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
1
[ RTECS ]:
GP8280000
Precursor & DownStream
Precursor
DownStream
Articles
Chem. Res. Toxicol. 23 , 171-83, (2010)
Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...
Phytantriol-based in situ liquid crystals with long-term release for intra-articular administration.AAPS PharmSciTech 16 , 846-54, (2015)
The purpose of this study was to develop an injectable in situ liquid crystal formulation for intra-articular (IA) administration, and in situ forming a viscous liquid crystalline gel with long-term r...
Microbeads: a novel multiparticulate drug delivery technology for increasing the solubility and dissolution of celecoxib.Pharm. Dev. Technol. 20(2) , 211-8, (2015)
The purpose of this study was to develop a novel multipaticulate drug delivery technology suitable for the delivery of pre-solubilized celecoxib to the gastrointestinal tract and more specifically to ...