3',4'-Dihydroxyflavonol

Names

[ Name ]:
3',4'-Dihydroxyflavonol

[Synonym ]:
3',4'-dihydroxyflavonol
3',4'-Dihydroxyflavonol
3,3',4'-TRIHYDROXYFLAVONE
3,3',4'-trihydroxyflavon
2-(3,4-dihydroxy-phenyl)-3-hydroxy-chromen-4-one

Biological Activity

[Description]:

3',4'-Dihydroxyflavonol (DiOHF) is an effective antioxidant, which reduces superoxide and improves nitric oxide (NO) function in diabetic rat mesenteric arteries[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Immunology/Inflammation >> NO Synthase

Research Areas >> Metabolic Disease

[In Vitro]

3',4'-Dihydroxyflavonol (DiOHF) acutely preserves nitric oxide (NO) activity in the presence of elevated reactive oxygen species (ROS). DiOHF improves NO activity in diabetes by reducing Nox2-dependent superoxide production and preventing eNOS uncoupling to improve endothelial function[1]. 3',4'-Dihydroxyflavonol reduces vascular contraction through Ca²⁺ desensitization in permeabilized third-order branches of rat mesenteric arteries[2].

[References]

[1]. Leo CH, et al. 3',4'-Dihydroxyflavonol reduces superoxide and improves nitric oxide function in diabetic rat mesenteric arteries. PLoS One. 2011;6(6):e20813.

[2]. Kim HY, et al. 3',4'-Dihydroxyflavonol reduces vascular contraction through Ca²⁺ desensitization in permeabilized rat mesenteric artery. Naunyn Schmiedebergs Arch Pharmacol. 2012 Feb;385(2):191-202.

Chemical & Physical Properties

[ Density]:
1.579g/cm3

[ Boiling Point ]:
508.9ºC at 760 mmHg

[ Molecular Formula ]:
C₁₅H₁₀O₅

[ Molecular Weight ]:
270.24

[ Flash Point ]:
198ºC

[ Exact Mass ]:
270.05300

[ PSA ]:
90.90000

[ LogP ]:
2.57680

[ Index of Refraction ]:
1.747

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310

[ RIDADR ]:
UN 2811 6.1 / PGIII

[ HS Code ]:
2914501900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914501900

[ Summary ]:
2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

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Related Compounds

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