N-Nitrosodimethylamine

Names

[ CAS No. ]:
62-75-9

[ Name ]:
N-Nitrosodimethylamine

[Synonym ]:
N-NITROSODIMETHYLAMINE
dimethyl-nitrosoamine
EINECS 200-549-8
N-Methyl-N-nitrosomethanamine
MFCD00002053
Methanamine,N-methyl-N-nitroso
Dimethylnitrosamine
Nitrosodimethylamine
DMNA
[14C]-Dimethylnitrosamine
N,N-Dimethylnitrosamine

Biological Activity

[Description]:

Dimethylnitrosamine (NDMA) is a potent hepatotoxin, carcinogen and mutagen. Dimethylnitrosamine can be used to induces liver tumors[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Haggerty HG, et, al. Role of metabolism in dimethylnitrosamine-induced immunosuppression: a review. Toxicology. 1990 Jul;63(1):1-23.

[2]. Takayama S, et, al. Sequential effects of chemically different carcinogens, dimethylnitrosamine and 4-dimethylaminoazobenzene, on hepatocarcinogenesis in rats. Int J Cancer. 1969 Jul 15;4(4):373-83.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
152.0±0.0 °C at 760 mmHg

[ Melting Point ]:
50ºC

[ Molecular Formula ]:
C₂H₆N₂O

[ Molecular Weight ]:
74.082

[ Flash Point ]:
36.1±18.7 °C

[ Exact Mass ]:
74.048012

[ PSA ]:
32.67000

[ LogP ]:
-0.64

[ Vapour Pressure ]:
4.6±0.2 mmHg at 25°C

[ Index of Refraction ]:
1.427

[ Stability ]:
Stability Stable, but light-sensitive. Combustible. Incompatible with strong oxidizing agents, strong bases, strong reducing agents.

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS02, GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H301 + H311 + H331-H350-H370

[ Precautionary Statements ]:
P201-P210-P260-P280-P301 + P310-P311

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T+,N,T,F

[ Risk Phrases ]:
45-25-26-48/25-51/53-39/23/24/25-23/24/25-11

[ Safety Phrases ]:
S53-S45-S61-S36/37

[ RIDADR ]:
UN 3382 6.1/PG 1

[ WGK Germany ]:
3

[ RTECS ]:
IQ0525000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

[Effect of cordyceps polysaccharide on lipid peroxidation of rats with dimethylnitrosamine-induced liver fibrosis].

Zhongguo Zhong Yao Za Zhi 38(3) , 391-6, (2013)

To observe the pharmacological effect of Cordyceps polysaccharide on dimethylnitrosamine (DMN)-induced liver fibrosis in rats.DMN rat liver fibrosis model was established and divided into the normal g...

Relationship between organic precursors and N-nitrosodimethylamine (NDMA) formation in tropical water sources.

J. Water Health 12(4) , 736-46, (2014)

The presence of organic compounds in water sources is one of the concerns in water treatment. They are potential precursors of disinfection byproducts (DBPs) and thus induce health problems in humans....

Developing structure-activity relationships for the prediction of hepatotoxicity.

Chem. Res. Toxicol. 23 , 1215-22, (2010)

Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals ...

Related Compounds

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