4-Ethoxyphenol
Names
[ CAS No. ]:
622-62-8
[ Name ]:
4-Ethoxyphenol
[Synonym ]:
Phenol,p-ethoxy
p-ethoxylphenol
4-Hydroxyphenetole
Phenol,4-ethoxy
1-hydroxy-4-ethoxybenzene
P-ETHOXYPHENOL
4-Ethoxybenzolol
EINECS 210-748-1
Hydroquinone monoethyl ether
4-Ethoxyphenol
Phenol, 4-ethoxy-
4-(ethyloxy)phenol
p-Hydroxyphenetole
MFCD00002334
4-ethoxy-phenol
Ethoxyphenol,p
Biological Activity
[Description]:
[Related Catalog]:
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
246.4±13.0 °C at 760 mmHg
[ Melting Point ]:
64-67 °C
[ Molecular Formula ]:
C8H10O2
[ Molecular Weight ]:
138.164
[ Flash Point ]:
124.0±4.8 °C
[ Exact Mass ]:
138.068085
[ PSA ]:
29.46000
[ LogP ]:
1.84
[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C
[ Index of Refraction ]:
1.527
[ Water Solubility ]:
slightly soluble
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SL3790000
- CHEMICAL NAME :
- Phenol, p-ethoxy-
- CAS REGISTRY NUMBER :
- 622-62-8
- BEILSTEIN REFERENCE NO. :
- 1907114
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C8-H10-O2
- MOLECULAR WEIGHT :
- 138.18
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- RBPMAZ Revue Belge de Pathologie et de Medecine Experimentale. (Brussels, Belgium) V.18-31, 1947-65. For publisher information, see PTEUA6. Volume(issue)/page/year: 22,1,1952 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 667 mg/kg
- SEX/DURATION :
- female 11 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
- REFERENCE :
- TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 41,43,1990
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn:Harmful;
[ Risk Phrases ]:
R22;R37/38;R41
[ Safety Phrases ]:
S37/39-S26-S36
[ RIDADR ]:
NONH for all modes of transport
[ RTECS ]:
SL3790000
[ HS Code ]:
2909500000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2909500000
[ Summary ]:
2909500000 ether-phenols, ether-alcohol-phenols and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%
Articles
Bioorg. Med. Chem. 17 , 896-904, (2009)
This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoret...
Cellular apoptosis and cytotoxicity of phenolic compounds: a quantitative structure-activity relationship study.J. Med. Chem. 48 , 7234-42, (2005)
In this comprehensive study on the caspase-mediated apoptosis-inducing effect of 51 substituted phenols in a murine leukemia cell line (L1210), we determined the concentrations needed to induce caspas...
Microperoxidase/H2O2-mediated alkoxylating dehalogenation of halophenol derivatives in alcoholic media.Proc. Natl. Acad. Sci. U. S. A. 94(9) , 4295-9, (1997)
The results of this study report the H2O2-driven microperoxidase-8 (MP8)-catalyzed dehalogenation of halophenols such as 4-fluorophenol, 4-chlorophenol, 4-bromophenol, and 2-fluorophenol in alcoholic ...