L-Alanine-d3

Names

[ Name ]:
L-Alanine-d3

[Synonym ]:
MFCD00084107
L-<3,3,3-2H3>alanine
L-(3,3,3-H)Alanine
l-alanine-d3
L-Alanine-3,3,3-d3
L-Alanine-3,3,3-d
alanine-C-d3

Biological Activity

[Description]:

L-Alanine-d3 (L-2-Aminopropionic acid-d3) is the deuterium labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.

[Related Catalog]:

Research Areas >> Metabolic Disease

Research Areas >> Neurological Disease

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
212.9±23.0 °C at 760 mmHg

[ Melting Point ]:
314.5ºC (dec.)(lit.)

[ Molecular Formula ]:
C₃H₄D₃NO₂

[ Molecular Weight ]:
92.112

[ Flash Point ]:
82.6±22.6 °C

[ Exact Mass ]:
92.066505

[ PSA ]:
63.32000

[ LogP ]:
-0.68

[ Vapour Pressure ]:
0.1±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.460

[ Storage condition ]:
2-8°C

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Towards the chiral metabolomics: Liquid chromatography-mass spectrometry based DL-amino acid analysis after labeling with a new chiral reagent, (S)-2,5-dioxopyrrolidin-1-yl-1-(4,6-dimethoxy-1,3,5-triazin-2-yl)pyrrolidine-2-carboxylate, and the application to saliva of healthy volunteers.

Anal. Chim. Acta 875 , 73-82, (2015)

A novel triazine-type chiral derivatization reagent, i.e., (S)-2,5-dioxopyrrolidin-1-yl-1-(4,6-dimethoxy-1,3,5-triazin-2-yl) pyrrolidine-2-carboxylate (DMT-(S)-Pro-OSu), was developed for the highly s...

Metabolomics study of hepatocellular carcinoma: discovery and validation of serum potential biomarkers by using capillary electrophoresis-mass spectrometry.

J. Proteome Res. 13(7) , 3420-31, (2014)

Hepatocellular carcinoma (HCC) is one of the most lethal malignancies. The lack of effective screening methods for early diagnosis has been a longstanding bottleneck to improve the survival rate. In t...

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.