3-amino-2-chloro-6-(trifluoromethyl)pyridine

Names

[ Name ]:
3-amino-2-chloro-6-(trifluoromethyl)pyridine

[Synonym ]:
2-<o-Hydroxy-phenyl>-1,8-naphthyridin

Biological Activity

[Description]:

2-NP is a selective enhancer of STAT1 transcription. 2-NP can enhance the ability of IFN-γ to inhibit the proliferation of human breast cancer and fibrosarcoma cells[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> STAT

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> STAT

[References]

[1]. Lynch RA, et, al. A small-molecule enhancer of signal transducer and activator of transcription 1 transcriptional activity accentuates the antiproliferative effects of IFN-gamma in human cancer cells. Cancer Res. 2007 Feb 1;67(3):1254-61.

Chemical & Physical Properties

[ Melting Point ]:
92-94ºC

[ Molecular Formula ]:
C₁₄H₁₀N₂O

[ Molecular Weight ]:
222.24200

[ Exact Mass ]:
222.07900

[ PSA ]:
46.01000

[ LogP ]:
3.00240

[ Appearance of Characters ]:
orange

[ Storage condition ]:
room temp

[ Water Solubility ]:
DMSO: ≥10mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H318

[ Precautionary Statements ]:
P280-P305 + P351 + P338

[ Hazard Codes ]:
Xn,T

[ Risk Phrases ]:
22-41-36-25

[ Safety Phrases ]:
26-39-45

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Related Compounds

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