Dimethyl sulfone
Names
[ CAS No. ]:
67-71-0
[ Name ]:
Dimethyl sulfone
[Synonym ]:
MFCD00007566
methylsulphonylmethane
Dimethylsulfon
MSM
Methyl sulfone
EINECS 200-665-9
Methylsulfone
METHYLSULPHONE
Sulfone,dimethyl
DIMETHYL SULPHONE
DMSO2
dimethyl sulfone
Biological Activity
[Description]:
[Related Catalog]:
[Target]
Human Endogenous Metabolite
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
240.9±8.0 °C at 760 mmHg
[ Melting Point ]:
107-109 °C(lit.)
[ Molecular Formula ]:
C2H6O2S
[ Molecular Weight ]:
94.133
[ Flash Point ]:
143.3±0.0 °C
[ Exact Mass ]:
94.008850
[ PSA ]:
42.52000
[ LogP ]:
-1.19
[ Vapour Pressure ]:
0.1±0.5 mmHg at 25°C
[ Index of Refraction ]:
1.402
[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents.
[ Water Solubility ]:
150 g/L (20 ºC)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- PB2785000
- CHEMICAL NAME :
- Methane, sulfonylbis-
- CAS REGISTRY NUMBER :
- 67-71-0
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C2-H6-O2-S
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533525
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533525
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
Xn
[ Safety Phrases ]:
S22-S24/25
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
1
[ RTECS ]:
PB2785000
[ HS Code ]:
29309070
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2904100000
[ Summary ]:
2904100000 derivatives containing only sulpho groups, their salts and ethyl esters。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%
Articles
J. Agric. Food Chem. 63 , 7511-21, (2015)
To establish the odor profiles of three differently fabricated commercial Swiss Tilsit cheeses, analyses were conducted using headspace solid-phase microextraction gas chromatography-mass spectrometry...
The human cerebrospinal fluid metabolomeJ. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 871(2) , 164-73, (2008)
With continuing improvements in analytical technology and an increased interest in comprehensive metabolic profiling of biofluids and tissues, there is a growing need to develop comprehensive referenc...
Methyl Sulfone Blocked Multiple Hypoxia- and Non-Hypoxia-Induced Metastatic Targets in Breast Cancer Cells and Melanoma Cells.PLoS ONE 10 , e0141565, (2015)
Metastatic cancer causes 90% of cancer deaths. Unlike many primary tumors, metastatic tumors cannot be cured by surgery alone. Metastatic cancer requires chemotherapy. However, metastatic cells are no...