Glutathione
Names
[ CAS No. ]:
70-18-8
[ Name ]:
Glutathione
[Synonym ]:
L-Glutathione Reduced
Tathion
L-Norvaline, 5-[[(1R,2Z)-2-[(carboxymethyl)imino]-2-hydroxy-1-(mercaptomethyl)ethyl]imino]-5-hydroxy-, (5Z)-
(5Z)-5-({(1Z,2R)-1-[(Carboxymethyl)imino]-1-hydroxy-3-sulfanyl-2-propanyl}imino)-5-hydroxy-L-norvaline
Deltathione
Glycine, N- (N-L-γ-glutamyl-L-cysteinyl)-
L-γ-Glutamyl-L-cysteinylglycine
Copren
Glycine, L-γ-glutamyl-L-cysteinyl-
Isethion
Glutathione reduced
GSH
Glutathione
Reduced glutathione
(2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid
L-γ-Glutamyl-L-cysteiylglycin
Glutathiol
MFCD00065939
EINECS 200-725-4
(2S)-2-Amino-5-({(2R)-1-[(carboxymethyl)amino]-1-oxo-3-sulfanyl-2-propanyl}amino)-5-oxopentanoic acid
Glutathione-SH
N-(N-L-g-Glutamyl-L-cysteinyl)glycine
Glutinal
L-Glutathione
γ-glutamyl-cysteinyl-glycine
Biological Activity
[Description]:
[Related Catalog]:
[Target]
Human Endogenous Metabolite
[In Vitro]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Boiling Point ]:
754.5±60.0 °C at 760 mmHg
[ Melting Point ]:
182-192ºC
[ Molecular Formula ]:
C10H17N3O6S
[ Molecular Weight ]:
307.323
[ Flash Point ]:
410.1±32.9 °C
[ Exact Mass ]:
307.083801
[ PSA ]:
197.62000
[ LogP ]:
-0.87
[ Vapour Pressure ]:
0.0±5.5 mmHg at 25°C
[ Index of Refraction ]:
1.572
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- MC0556000
- CHEMICAL NAME :
- Glycine, N-(N-L-gamma-glutamyl-L-cysteinyl)-
- CAS REGISTRY NUMBER :
- 70-18-8
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 20
- MOLECULAR FORMULA :
- C10-H17-N3-O6-S
- MOLECULAR WEIGHT :
- 307.36
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4020 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2238 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1250 mg/kg
- SEX/DURATION :
- female 1-22 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
MUTATION DATA
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Mammal - species unspecified Lymphocyte
- DOSE/DURATION :
- 10 mmol/L
- REFERENCE :
- CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 31,265,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83371 No. of Facilities: 174 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1744 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83371 No. of Facilities: 238 (estimated) No. of Industries: 1 No. of Occupations: 7 No. of Employees: 3078 (estimated) No. of Female Employees: 2121 (estimated)
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
Xi: Irritant;
[ Risk Phrases ]:
R68
[ Safety Phrases ]:
S24/25
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
2
[ RTECS ]:
MC0556000
[ HS Code ]:
2930909090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2930909090
[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Articles
Biochem. J. 467(2) , 345-52, (2015)
Ubiquitylation regulates a multitude of biological processes and this versatility stems from the ability of ubiquitin (Ub) to form topologically different polymers of eight different linkage types. Wh...
A survey of the interactome of Kaposi's sarcoma-associated herpesvirus ORF45 revealed its binding to viral ORF33 and cellular USP7, resulting in stabilization of ORF33 that is required for production of progeny viruses.J. Virol. 89(9) , 4918-31, (2015)
The ORF45 protein of Kaposi's sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus-specific immediate-early tegument protein. Our previous studies have revealed its crucial roles in both early ...
Phospho-tyrosine dependent protein-protein interaction network.Mol. Syst. Biol. 11(3) , 794, (2015)
Post-translational protein modifications, such as tyrosine phosphorylation, regulate protein-protein interactions (PPIs) critical for signal processing and cellular phenotypes. We extended an establis...