tert-Butylamine

Names

[ CAS No. ]:
75-64-9

[ Name ]:
tert-Butylamine

[Synonym ]:
T-BUTYLAMINE
Butylamine,tert
MFCD00008050
tert-Butylamine
erbumine
tert-C4H9NH2
1-amino-1,1-dimethylethane
butylamine,tertiary
2-methyl-2-propaneamine
1,1-dimethyl-ethylamine
2-amino-2-methylpropane
2-AMINOISOBUTANE
Ter-butyl amine
EINECS 200-888-1
Clavulanate Potassium Impurity 8

Chemical & Physical Properties

[ Density]:
0.696 g/mL at 25 °C(lit.)

[ Boiling Point ]:
46 °C(lit.)

[ Melting Point ]:
-67 °C

[ Molecular Formula ]:
C₄H₁₁N

[ Molecular Weight ]:
73.13680

[ Flash Point ]:
−36.4 °F

[ Exact Mass ]:
73.08910

[ PSA ]:
26.02000

[ LogP ]:
1.44390

[ Vapour density ]:
2.5 (vs air)

[ Vapour Pressure ]:
5.7 psi ( 20 °C)

[ Index of Refraction ]:
n20/D 1.377(lit.)

[ Stability ]:
Stable. Incompatible with strong acids, strong oxidizing agents. Highly flammable.

[ Water Solubility ]:
MISCIBLE

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EO3330000

CHEMICAL NAME :: tert-Butylamine

CAS REGISTRY NUMBER :: 75-64-9

LAST UPDATED :: 199806

DATA ITEMS CITED :: 16

MOLECULAR FORMULA :: C4-H11-N

MOLECULAR WEIGHT :: 73.16

WISWESSER LINE NOTATION :: ZX1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 40 mg/m3/8H-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - visual field changes Sense Organs and Special Senses (Eye) - corneal damage Sense Organs and Special Senses (Eye) - effect, not otherwise specified

REFERENCE :: BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944- Volume(issue)/page/year: 48,26,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 44 mg/kg

TOXIC EFFECTS :: Behavioral - food intake (animal) Lungs, Thorax, or Respiration - pulmonary emboli Liver - other changes

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0534846

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3800 mg/m3/4H

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ptosis Lungs, Thorax, or Respiration - dyspnea Blood - hemorrhage

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0570798

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 50(12),70,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 378 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 50(12),70,1985

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Gastrointestinal - other changes

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0570521

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 375 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 50(12),70,1985 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2010 mg/m3/6H/13W-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0538640 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-DENMARK:STEL 5 ppm (15 mg/m3);Skin JAN 1993 OEL-GERMANY:TWA 5 ppm (15 mg/m3);Skin JAN 1993 OEL-SWITZERLAND:TWA 5 ppm (15 mg/m3);STEL 25 ppm (75 mg/m3) JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 14444 No. of Facilities: 219 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 1268 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 14444 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 4354 (estimated) No. of Female Employees: 729 (estimated)

Safety Information

[ Symbol ]:

GHS02, GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H302-H314-H331-H412

[ Precautionary Statements ]:
P210-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338-P403 + P233

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US)

[ Hazard Codes ]:
F:Flammable

[ Risk Phrases ]:
R11;R20;R25;R35

[ Safety Phrases ]:
S16-S26-S36/37/39-S45-S28A

[ RIDADR ]:
UN 3286 3/PG 2

[ WGK Germany ]:
1

[ RTECS ]:
EO3330000

[ Packaging Group ]:
II

[ Hazard Class ]:
3

[ HS Code ]:
29211980

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 29211980

Articles

Multilayered Thin Films from Boronic Acid-Functional Poly(amido amine)s.

Pharm. Res. 32(9) , 3066-86, (2015)

To investigate the properties of phenylboronic acid-functional poly(amido amine) polymers (BA-PAA) in forming multilayered thin films with poly(vinyl alcohol) (PVA) and chondroitin sulfate (ChS), and ...

Ion chromatography of amylamine and tert.-butylamine in pharmaceuticals.

J. Chromatogr. A. 739(1-2) , 343-9, (1996)

Ion chromatographic (IC) methods have been developed for the assay of amylamine in BMS-181 866-02 and tert.-butylamine (TBA) in BMS-188 494-04. BMS-181 866-02 is the penultimate intermediate in the sy...

[Hygienic standard for tert-butylamine in water].

Gig. Sanit. (12) , 70-1, (1985)

Related Compounds

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