Pinacidil hydrate

Names

[ Name ]:
Pinacidil hydrate

[Synonym ]:
Pinacidil (hydrate)
Pinacidil . monohydrate
1-Cyano-3-(3,3-dimethylbutan-2-yl)-2-pyridin-4-ylguanidine hydrate (1:1)
(+/-)-N-Cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)guanidine
MFCD00242745
Hndac
GUANIDINE,N-CYANO-N'-4-PYRIDINYL-N''-(1,2,2-TRIMETHYLPROPYL)-, HYDRATE (1:1)
Guanidine, N''-cyano-N-4-pyridinyl-N'-(1,2,2-trimethylpropyl)-, hydrate (1:1)
Guanidine,N-cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)-,monohydrate
Pinacidil monohydrate
EINECS 262-294-9
Pinacidil hydrate
1-Cyano-2-(3,3-dimethyl-2-butanyl)-3-(4-pyridinyl)guanidine hydrate (1:1)

Biological Activity

[Description]:

Pinacidil monohydrate, an antihypertensive drug, is a potassium channel activator.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

Research Areas >> Others

[In Vitro]

Pinacidil monohydrate is a potassium channel activator[1]. Pinacidil hydrate is an antihypertensive drug of the class of agents called "potassium channel openers"[2]. Pinacidil hydrate activates the ATP-modulated potassium channels of guinea pog bladder and heart with Ki values of 104 and 251 nM, respectively[3].

[References]

[1]. Buckle DR, et al. Relaxant effects of the potassium channel activators BRL 38227 and pinacidil on guinea-pig and human airway smooth muscle, and blockade of their effects by glibenclamide and BRL 31660. Pulm Pharmacol. 1993 Mar;6(1):77-86.

[2]. Bareggi SR, et al. Pharmacodynamics and pharmacokinetics of pinacidil in normotensive volunteers after repeated doses of a new slow-release tablet formulation. Arzneimittelforschung. 1999 Jan;49(1):21-5.

[3]. Gollasch M, et al. Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cells. J Pharmacol Exp Ther. 1995 Nov;275(2):681-92.

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
356.7ºC at 760 mmHg

[ Melting Point ]:
164-165ºC

[ Molecular Formula ]:
C₁₃H₂₁N₅O

[ Molecular Weight ]:
263.34

[ Flash Point ]:
169.5ºC

[ PSA ]:
73.10000

[ LogP ]:
2.94578

[ Storage condition ]:
2-8℃

[ Water Solubility ]:
ethanol: 14 mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933399090

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Related Compounds

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