DPC

Names

[ CAS No. ]:
886-38-4

[ Name ]:
DPC

[Synonym ]:
2,3-Diphenyl-2-cyclopropen-1-one
2,3-diphenylcycloprop-2-en-1-one
1,2-Diphenylcyclopropen-3-one
2,3-Diphenylcycloprop-2-en-1-on
DPC
DPC (VAN)
2-Cyclopropen-1-one, 2,3-diphenyl-
EINECS 212-948-4
MFCD00001311
DIPHENYLCYCLOPROPENONE
1,2-Diphenylcyclopropenone

Biological Activity

[Description]:

Diphenylcyclopropenone (Diphencyprone) is a topical immunomodulatory agent that can be used for alopecia areata research[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Yugang Gong, et al. Diphenylcyclopropenone plays an effective therapeutic role by up-regulating the TSLP/OX40L/IL-13 pathway in severe alopecia areata. Exp Dermatol. 2021 Feb;30(2):278-283.

[2]. Zekayi Kutlubay, et al. Assessment of treatment efficacy of diphenylcyclopropenone (DPCP) for alopecia areata. Turk J Med Sci. 2020 Dec 17;50(8):1817-1824.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
407.2±45.0 °C at 760 mmHg

[ Melting Point ]:
118-122 °C(lit.)

[ Molecular Formula ]:
C₁₅H₁₀O

[ Molecular Weight ]:
206.239

[ Flash Point ]:
182.7±23.7 °C

[ Exact Mass ]:
206.073166

[ PSA ]:
17.07000

[ LogP ]:
3.78

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.669

[ Storage condition ]:
Refrigerator (+4°C)

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H317

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R43

[ Safety Phrases ]:
S36/37

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Differential signaling by regulatory subunits of phosphoinositide-3-kinase influences cell survival in INS-1E insulinoma cells.

Exp. Clin. Endocrinol. Diabetes 123(2) , 118-25, (2015)

Class 1A phosphoinositide 3-kinase (PI3K) is essential for beta-cell growth and survival. Although PI3K has been studied extensively in diabetes the effect of alternatively spliced isoforms of the cat...

Spider wrapping silk fibre architecture arising from its modular soluble protein precursor.

Sci. Rep. 5 , 11502, (2015)

Spiders store spidroins in their silk glands as high concentration aqueous solutions, spinning these dopes into fibres with outstanding mechanical properties. Aciniform (or wrapping) silk is the tough...

Disease mutations in desmoplakin inhibit Cx43 membrane targeting mediated by desmoplakin-EB1 interactions.

J. Cell Biol. 206(6) , 779-97, (2014)

Mechanisms by which microtubule plus ends interact with regions of cell-cell contact during tissue development and morphogenesis are not fully understood. We characterize a previously unreported inter...

Related Compounds

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