Ethylene methacrylate

Names

[ CAS No. ]:
97-90-5

[ Name ]:
Ethylene methacrylate

[Synonym ]:
Ethylene methacrylate
Ethylene dimethacrylate
Glycol dimethacrylate
Ethane-1,2-diyl bis(2-methylprop-2-enoate)
1UY1&VO2OVY1&U1
MFCD00008590
2-Propenoic acid, 2-methyl-, 1,2-ethanediyl ester
Ethyldiol methacrylate
Ethane-1,2-diyl bis(2-methylacrylate)
EINECS 202-617-2
1,2-Ethanediyl bis(2-methylacrylate)
Methacrylic acid ethylene ester
1,2-Ethanediol dimethacrylate
Ethylene glycol dimethacrylate

Biological Activity

[Description]:

Ethylene glycol dimethacrylate is a methacrylate monomer, exhibits cytotoxic and genotoxic effects on human gingival fibroblasts (HGFs). Ethylene glycol dimethacrylate increases intracellular reactive oxygen species (ROS) production, causes DNA damage, increases apoptosis and causes cell cycle arrest in G1/G0 phase[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Others

[References]

[1]. Anna Bielecka-Kowalska, et al. Ethylene glycol dimethacrylate and diethylene glycol dimethacrylate exhibits cytotoxic and genotoxic effect on human gingival fibroblasts via induction of reactive oxygen species. Toxicol In Vitro. 2018 Mar:47:8-17.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
260.6±13.0 °C at 760 mmHg

[ Melting Point ]:
-40 °C

[ Molecular Formula ]:
C₁₀H₁₄O₄

[ Molecular Weight ]:
198.216

[ Flash Point ]:
121.8±18.2 °C

[ Exact Mass ]:
198.089203

[ PSA ]:
52.60000

[ LogP ]:
2.78

[ Vapour density ]:
>1 (vs air)

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.449

[ Stability ]:
Unstable - may polymerize upon exposure to light. Incompatible with strong acids, strong oxidizing agents, strong bases.

[ Water Solubility ]:
soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OZ4400000

CHEMICAL NAME :: Methacrylic acid, ethylene ester

CAS REGISTRY NUMBER :: 97-90-5

BEILSTEIN REFERENCE NO. :: 1776663

LAST UPDATED :: 199710

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C10-H14-O4

MOLECULAR WEIGHT :: 198.24

WISWESSER LINE NOTATION :: 1UY1&VO2OVY1&U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - mouse Lymphocyte

DOSE/DURATION :: 5820 umol/L

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 17,264,1991 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M3204 No. of Facilities: 983 (estimated) No. of Industries: 3 No. of Occupations: 7 No. of Employees: 6295 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M3204 No. of Facilities: 562 (estimated) No. of Industries: 8 No. of Occupations: 14 No. of Employees: 9073 (estimated) No. of Female Employees: 3604 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H317-H335

[ Precautionary Statements ]:
P280-P304 + P340 + P312-P333 + P313

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R37;R43

[ Safety Phrases ]:
S24-S37

[ RIDADR ]:
UN3334 9

[ WGK Germany ]:
1

[ RTECS ]:
OZ4400000

[ Hazard Class ]:
9.0

[ HS Code ]:
2916140000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2916190090

[ Summary ]:
2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

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Related Compounds

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