SAH

Names

[ CAS No. ]:
979-92-0

[ Name ]:
SAH

[Synonym ]:
S-(5'-Adenosyl)-L-homocysteine
(2S)-adenosylhomocysteine
Adenosylhomocysteine
Adenosyl-L-homocysteine
AdenosylhoMocysteine-13C5
(2S)-2-Amino-4-({[(2S,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydro-2-furanyl]methyl}sulfanyl)butanoic acid (non-preferred name)
HOMOCYSTEINE,S-ADENOSYL
L-S-AdenosylhoMocysteine
s-adenosylhomocysteine
S-ADENOSYL-L-HOMOCYSTEINE
L-adenosyl-L-homocysteine
hpce
ADOHCY
5'-DEOXY-S-ADENOSYL

Biological Activity

[Description]:

SAH is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine.

[Related Catalog]:

Natural Products >> Acids and Aldehydes

Research Areas >> Others

[Target]

Human Endogenous Metabolite

[References]

[1]. DE LA HABA G, et al. The enzymatic synthesis of S-adenosyl-L-homocysteine from adenosine and homocysteine. J Biol Chem. 1959 Mar;234(3):603-8.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.9±0.1 g/cm3

[ Boiling Point ]:
787.5±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₄H₂₀N₆O₅S

[ Molecular Weight ]:
384.411

[ Flash Point ]:
430.0±35.7 °C

[ Exact Mass ]:
384.121582

[ PSA ]:
207.93000

[ LogP ]:
0.15

[ Appearance of Characters ]:
crystalline

[ Vapour Pressure ]:
0.0±2.9 mmHg at 25°C

[ Index of Refraction ]:
1.839

[ Storage condition ]:
−20°C

[ Water Solubility ]:
1 M HCl: soluble19.60 - 20.40mg/mL, clear to slightly hazy, colorless to faintly yellow

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

EZH2 modulates angiogenesis in vitro and in a mouse model of limb ischemia.

Mol. Ther. 23(1) , 32-42, (2015)

Epigenetic mechanisms may regulate the expression of pro-angiogenic genes, thus affecting reparative angiogenesis in ischemic limbs. The enhancer of zest homolog-2 (EZH2) induces thtrimethylation of l...

Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression.

Nature 457(7231) , 910-4, (2009)

Multiple, complex molecular events characterize cancer development and progression. Deciphering the molecular networks that distinguish organ-confined disease from metastatic disease may lead to the i...

Characterization of RimO, a new member of the methylthiotransferase subclass of the radical SAM superfamily.

Biochemistry 48(42) , 10162-74, (2009)

RimO, encoded by the yliG gene in Escherichia coli, has been recently identified in vivo as the enzyme responsible for the attachment of a methylthio group on the beta-carbon of Asp88 of the small rib...

Related Compounds

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