Brompheniramine Maleate

Names

[ CAS No. ]:
980-71-2

[ Name ]:
Brompheniramine Maleate

[Synonym ]:
(±)-2-[p-Bromo-a-(2-dimethylaminoethyl)benzyl]pyridine Maleate
D-Brompheniramine
dl-Bromopheniramine Maleate
Brompheniramine Maleate
(±)-Brompheniramine maleate
3-(4-Bromophenyl)-N,N-dimethyl-3-(2-pyridinyl)-1-propanamine (2Z)-2-butenedioate (1:1)
Brompheniramine d
3-(4-Bromophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine (2Z)-but-2-enedioate (1:1)
(+/-)-1-(4-bromophenyl)-1-(2-pyridyl)-3-dimethylaminopropane
2-pyridinepropanamine, g-(4-bromophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1)
Ilvin Maleate
(RS)-brompheniramine
MFCD00057367
EINECS 213-562-9
PARABROMODYLAMINE MALEATE
brompheniramine hydrogen maleate
2-Pyridinepropanamine, γ-(4-bromophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1)
acide (2Z)-but-2-ènedioïque - 3-(4-bromophényl)-N,N-diméthyl-3-pyridin-2-ylpropan-1-amine (1:1)
3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine (2Z)-but-2-enedioate
(2Z)-But-2-endisäure--3-(4-bromphenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amin(1:1)
brompheniramine (maleate)
N-(3-THIOXO-3H-1,2,4-DITHIAZOL-5-YL)-2-THIOPHENECARBOXAMIDE

Biological Activity

[Description]:

Brompheniramine maleate is a histamine H1 receptors antagonist.Target: Histamine H1 ReceptorBrompheniramine maleate, is an antihistamine drug of the propylamine (alkylamine) class. It is readily available over the counter and is indicated for the treatment of the symptoms of the common cold and allergic rhinitis. It is a first-generation antihistamine. Brompheniramine has antidepressant properties, inhibiting reuptake of the neurotransmitter serotonin. Based on this knowledge, Arvid Carlsson and his colleagues, working at the Swedish company Astra AB, were able to derive the first marketed selective serotonin reuptake inhibitor, zimelidine, from brompheniramine. Brompheniramine had a long half-life and large volume of distribution in normal adults. It also had a prolonged antihistaminic effect in the skin as evidenced by suppression of the wheal and flare response to histamine and by suppression of pruritus [1, 2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor

Research Areas >> Inflammation/Immunology

[References]

[1]. http://en.wikipedia.org/wiki/Brompheniramine

[2]. Simons, F.E., E.M. Frith, and K.J. Simons, The pharmacokinetics and antihistaminic effects of brompheniramine. J Allergy Clin Immunol, 1982. 70(6): p. 458-64.

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
403ºC at 760 mmHg

[ Melting Point ]:
134-135ºC

[ Molecular Formula ]:
C₂₀H₂₃BrN₂O₄

[ Molecular Weight ]:
435.312

[ Exact Mass ]:
434.084106

[ PSA ]:
90.73000

[ LogP ]:
3.63950

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: US4025000

CAS REGISTRY NUMBER :: 980-71-2

LAST UPDATED :: 199710

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C16-H19-Br-N2.C4-H4-O4

MOLECULAR WEIGHT :: 435.36

WISWESSER LINE NOTATION :: T6NJ BYR DE&2N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 318 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,19,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 76 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,19,1969 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84807 No. of Facilities: 967 (estimated) No. of Industries: 3 No. of Occupations: 9 No. of Employees: 3990 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84807 No. of Facilities: 314 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 6708 (estimated) No. of Female Employees: 3572 (estimated)

Safety Information

[ Symbol ]:

GHS02, GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H301 + H311 + H331-H370

[ Precautionary Statements ]:
P210-P260-P280-P301 + P310-P311

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S36

[ RIDADR ]:
UN 3249

[ WGK Germany ]:
3

[ RTECS ]:
US4025000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2934999090

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Related Compounds

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