260443-89-8

260443-89-8 structure

Name: 5F 203
Chemical Name: 4-(5-fluoro-1,3-benzothiazol-2-yl)-2-methylaniline
CAS Number: 260443-89-8
Molecular Formula: C₁₄H₁₁FN₂S
Molecular Weight: 258.31400
Catalog: Signaling Pathways Immunology/Inflammation Aryl Hydrocarbon Receptor
Create Date: 2017-06-29 02:40:17
Modify Date: 2024-01-05 19:27:29
5F-203 (NSC-703786) is a cytotoxic molecule that forms DNA adducts and cell cycle arrest. 5F-203 induces aryl hydrocarbon receptor (AhR) signaling and elevates expression of CYP1A1. 5F-203 also increases the levels of reactive oxygen species as well as activates JNK, ERK, and p38[1][2][3].

Name	4-(5-fluoro-1,3-benzothiazol-2-yl)-2-methylaniline
Synonyms	4-(5-fluorobenzothiazol-2-yl)-2-methylphenylamine 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole

Description	5F-203 (NSC-703786) is a cytotoxic molecule that forms DNA adducts and cell cycle arrest. 5F-203 induces aryl hydrocarbon receptor (AhR) signaling and elevates expression of CYP1A1. 5F-203 also increases the levels of reactive oxygen species as well as activates JNK, ERK, and p38[1][2][3].
Related Catalog	Research Areas >> Others Signaling Pathways >> Immunology/Inflammation >> Aryl Hydrocarbon Receptor
References	[1]. Hutchinson I, et al. Antitumor benzothiazoles. 16. Synthesis and pharmaceutical properties of antitumor 2-(4-aminophenyl)benzothiazole amino acid prodrugs. J Med Chem. 2002 Jan 31;45(3):744-7. [2]. Hose CD, et al. Induction of CYP1A1 in tumor cells by the antitumor agent 2-[4-amino-3-methylphenyl]-5-fluoro-benzothiazole: a potential surrogate marker for patient sensitivity. Mol Cancer Ther. 2003 Dec;2(12):1265-72. [3]. Callero MA, et al. Biomarkers of sensitivity to potent and selective antitumor 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F203) in ovarian cancer. J Cell Biochem. 2013 Oct;114(10):2392-404.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
RIDADR	NONH for all modes of transport