74515-39-2

74515-39-2 structure

Name: LY125180
Chemical Name: N,N-dimethyl-3-(4-methylphenoxy)-1-phenylpropan-1-amine,hydrochloride
CAS Number: 74515-39-2
Molecular Formula: C₁₈H₂₄ClNO
Molecular Weight: 305.84
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2018-06-20 22:27:42
Modify Date: 2024-03-05 16:39:22
LY125180 is a serotonin uptake inhibitor. LY125180 competitively inhibits the uptake of serotonin and norepinephrine by cortical synaptosomes and of dopamine by striatal synaptosomes, with Ki values of 0.06 μM, 2.2 μM and 2.5 μM respectively[1].

Name	N,N-dimethyl-3-(4-methylphenoxy)-1-phenylpropan-1-amine,hydrochloride
Synonyms	N,N-dimethyl-3-(4-methylphenoxy)-1-phenylpropan-1-amine hydrochloride

Description	LY125180 is a serotonin uptake inhibitor. LY125180 competitively inhibits the uptake of serotonin and norepinephrine by cortical synaptosomes and of dopamine by striatal synaptosomes, with Ki values of 0.06 μM, 2.2 μM and 2.5 μM respectively[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
References	[1]. Wong DT, et al. N,N-Dimethyl-alpha-[2-(p-tolyloxy)ethyl]benzylamine hydrochloride (LY125180). Effects on serotonin uptake and serotonin synthesis in rat brain in vitro and in vivo. Biochem Pharmacol. 1980 Mar 15;29(6):935-41.