Adrenergic receptors are a class of G protein-coupled receptors that are targets of the catecholamines, especially norepinephrine and epinephrine. Many cells possess these receptors, and the binding of a catecholamine to the receptor will generally stimulate the sympathetic nervous system. The sympathetic nervous system is responsible for the fight-or-flight response, which includes widening the pupils of the eye, mobilizing energy, and diverting blood flow from non-essential organs to skeletal muscle. There are two main groups of adrenergic receptors, α and β, with several subtypes. α receptors have the subtypes α1 and α2. β receptors have the subtypes β1, β2 and β3. All three are linked to Gs proteins, which in turn are linked to adenylate cyclase. Agonist binding thus causes a rise in the intracellular concentration of the second messenger cAMP. Downstream effectors of cAMP include cAMP-dependent protein kinase (PKA), which mediates some of the intracellular events following hormone binding.


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Scopine

Scopine is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock. Target: α1-Adrenergic ReceptorScopine is a tropane alkaloid found in a variety of plants including Mandragora root, Senecio mikanoides (Delairea odorata), Scopolia carniolica and Scopolia lurida. Scopine can be prepared by the hydrolysis of scopolamine. From Wikipedia.

  • CAS Number: 498-45-3
  • MF: C8H13NO2
  • MW: 155.194
  • Catalog: Adrenergic Receptor
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 281.3±40.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 123.9±27.3 °C

Imiloxan hydrochloride

Imiloxan hydrochloride is a potent and selective alpha 2B-adrenoceptor antagonist. Imiloxan hydrochloride has the potential for acute kidney injury research[1][2].

  • CAS Number: 81167-22-8
  • MF: C14H17ClN2O2
  • MW: 280.75
  • Catalog: Adrenergic Receptor
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

LEVOBUNOLOL

Levobunolol (l-Bunolol) is a potent and nonselective β-adrenergic receptor antagonist. Levobunolol is an ocular hypotensive agent and lowers mean intraocular pressure (IOP). Levobunolol can be used for glaucoma and superior oblique myokymia (SOM) research[1][2][3].

  • CAS Number: 47141-42-4
  • MF: C17H25NO3
  • MW: 291.38500
  • Catalog: Adrenergic Receptor
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: 205 - 210ºC
  • Flash Point: N/A

Dapiprazole

Dapiprazole is a potent, selective and orally active alpha-1 adrenoceptor antagonist. Dapiprazole suppresses the opioid withdrawal symptoms. Dapiprazole is also used as eye drops for reversing mydriasis[1][2][3].

  • CAS Number: 72822-12-9
  • MF: C19H27N5
  • MW: 325.451
  • Catalog: Adrenergic Receptor
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 538.9±60.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 279.7±32.9 °C

(rac)-Nebivolol-d4

(Rac)-Nebivolol-d4 ((Rac)-R 065824-d4) is a labelled racemic Nebivolol. Nebivolol selectively inhibits β1- adrenergic receptor with IC50 of 0.8 nM[1][2].

  • CAS Number: 1219407-55-2
  • MF: C22H21D4F2NO4
  • MW: 409.46
  • Catalog: Adrenergic Receptor
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Esmolol-d7 (hydrochloride)

Esmolol-d7 hydrochloride is the deuterium labeled Esmolol hydrochloride. Esmolol hydrochloride is a beta adrenergic receptor blocker[1][2].

  • CAS Number: 1346598-13-7
  • MF: C16H19D7ClNO4
  • MW: 338.878
  • Catalog: Autophagy
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Dobutamine hydrochloride

Dobutamine Hcl(Dobutrex) is a sympathomimetic drug used in the treatment of heart failure and cardiogenic shock. Its primary mechanism is direct stimulation of β1 receptors of the sympathetic nervous system.

  • CAS Number: 49745-95-1
  • MF: C18H24ClNO3
  • MW: 337.841
  • Catalog: Adrenergic Receptor
  • Density: N/A
  • Boiling Point: 527.7ºC at 760mmHg
  • Melting Point: 184-186ºC(lit.)
  • Flash Point: 169.8ºC

Phentolamine

Phentolamine is a potent, selective and orally active α1 adrenergic and α2 adrenergic receptor antagonist. Phentolamine can be used for the treatment of erectile dysfunction[1][2][3].

  • CAS Number: 50-60-2
  • MF: C17H19N3O
  • MW: 281.352
  • Catalog: Adrenergic Receptor
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 551.0±45.0 °C at 760 mmHg
  • Melting Point: 177 - 178ºC
  • Flash Point: 287.0±28.7 °C

Ro 363 hydrochloride

Ro 363 hydrochloride, an effective inotropic stimulant, is a potent and highly selective β1-adrenoceptor agonist. Ro 363 hydrochloride is a cardiovascular modulator that reduces diastolic blood pressure and pronounces increases in myocardial contractility[1][2][3].

  • CAS Number: 250580-70-2
  • MF: C19H26ClNO6
  • MW: 399.87
  • Catalog: Adrenergic Receptor
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Navafenterol

Navafenterol (AZD-8871) is an inhaled dual-acting, potent, selective, and long-lasting M3-antagonist/β2-agonist (MABA) with long-lasting effects and favorable safety profile. The pIC50 is 9.5 for human M3 receptor, and the pEC50 is 9.5 for β2-adrenoceptor. Navafenterol can be used for the research of chronic obstructive pulmonary disease (COPD). Bronchoprotective and antisialagogue effects. Favorable cardiovascular profile[1].

  • CAS Number: 1435519-06-4
  • MF: C38H42N6O6S2
  • MW: 742.91
  • Catalog: Adrenergic Receptor
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Brexpiprazole dihydrochloride

Brexpiprazole (OPC-34712) hydrochloride, an atypical orally active antipsychotic drug, is a partial agonist of human 5-HT1A and dopamine D2L receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole hydrochloride is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM. Brexpiprazole hydrochloride also shows potent antagonist activity at human noradrenergic α1B (Ki=0.17 nM) and α2C receptors (Ki=0.59 nM)[1][2].

  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

5-[2-[[3-(1,3-benzodioxol-5-yl)-1-methylpropyl]amino]-1-hydroxyethyl]salicylamide

Medroxalol (RMI81968) is an orally active adrenergic receptor antagonist, blocks α- and β-adrenergic receptors. Medroxalol shows antihypertensive and vasodilating effects[1].

  • CAS Number: 56290-94-9
  • MF: C20H24N2O5
  • MW: 372.41500
  • Catalog: Adrenergic Receptor
  • Density: 1.307g/cm3
  • Boiling Point: 604.1ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 319.1ºC

Fenspiride-d5 hydrochloride

Fenspiride-d5 hydrochloride is the deuterium labeled Fenspiride hydrochloride. Fenspiride hydrochloride is an α adrenergic and H1 histamine receptor antagonist[1][2].

  • CAS Number: 1246815-28-0
  • MF: C15H16D5ClN2O2
  • MW: 301.82
  • Catalog: Adrenergic Receptor
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

CL 316243 disodium salt

CL316243 is a highly potent selective β3-adrenoceptor agonist with a EC50 of 3 nM, but is an extremely poor to β1/2- receptors[1].CL316243 is a effective stimulant of adipocyte lipolysis and increases brown adipose tissue thermogenesis and metabolic rate[2]. CL316243 has the potential for the treatment obesity, diabetes and urge urinary incontinence[3].

  • CAS Number: 138908-40-4
  • MF: C20H18ClNNa2O7
  • MW: 465.79200
  • Catalog: Adrenergic Receptor
  • Density: N/A
  • Boiling Point: 689.5ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 370.8ºC

(+)-Sotalol

(+)-Sotalol ((S)-Sotalol) is the S-isomer of Sotalol (HY-103196). Sotalol is an orally active, non-selective β-adrenergic receptor blocker. (+)-Sotalol is an antiarrhythmic agent. (+)-Sotalol can prolong action potential duration in isolated cardiac muscle[1][2][3].

  • CAS Number: 30236-32-9
  • MF: C12H20N2O3S
  • MW: 272.36400
  • Catalog: Adrenergic Receptor
  • Density: 1.239g/cm3
  • Boiling Point: 443.3ºC at 760mmHg
  • Melting Point: N/A
  • Flash Point: 221.9ºC

Brombuterol D9

Brombuterol D9 (Bromobuterol D9) is a deuterium labeled Brombuterol. Brombuterol is a β-adrenergic receptor agonist[1].

  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Mapenterol hydrochloride

Mapenterol hydrochloride is a type of β2-adrenoceptor agonist[1].

  • CAS Number: 54238-51-6
  • MF: C14H21Cl2F3N2O
  • MW: 361.23100
  • Catalog: Adrenergic Receptor
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: 176-178℃ (Decomposition)
  • Flash Point: N/A

Clenbuterol hydrochloride

Clenbuterol hydrochloride (NAB-365 hydrochloride) is a β2 adrenergic receptor agonist. It is a powerful bronchodilator withfat burning properties.

  • CAS Number: 21898-19-1
  • MF: C12H19Cl3N2O
  • MW: 313.651
  • Catalog: Adrenergic Receptor
  • Density: 1.25g/cm3
  • Boiling Point: 404.9ºC at 760 mmHg
  • Melting Point: 174-175.5°C
  • Flash Point: 198.7ºC

Fenoterol-d6 hydrobromide

Fenoterol-d6 hydrobromide (Th-1165a-d6) is the deuterium labeled Fenoterol hydrobromide. Fenoterol hydrobromide (Th-1165a), a sympathomimetic agent, is a selective and orally active β2-adrenoceptor agonist. Fenoterol hydrobromide is an effective bronchodilator and can be used for bronchospasm associated with asthma, bronchitis and other obstructive airway diseases research[1][2].

  • CAS Number: 1286129-04-1
  • MF: C17H16BrD6NO4
  • MW: 390.30200
  • Catalog: Adrenergic Receptor
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Bunazosin Hydrochloride

Bunazosin hydrochloride is a potent and selective α1-adrenoceptor antagonist. Bunazosin hydrochloride can be used for antihypertensive and ocular hypotensive research[1].

  • CAS Number: 52712-76-2
  • MF: C19H28ClN5O3
  • MW: 409.91
  • Catalog: Adrenergic Receptor
  • Density: 1.221g/cm3
  • Boiling Point: 620.6ºC at 760mmHg
  • Melting Point: 280-282°
  • Flash Point: 329.1ºC

Practolol

Practolol is a potent and selective β1-adrenergic receptor antagonist. Practolol can be used for the research of cardiac arrhythmias[1][2][3].

  • CAS Number: 6673-35-4
  • MF: C14H22N2O3
  • MW: 266.33600
  • Catalog: Adrenergic Receptor
  • Density: 1.0807 (rough estimate)
  • Boiling Point: 409.54°C (rough estimate)
  • Melting Point: 134-136° (BuOAc)
  • Flash Point: N/A

Isoxsuprine hydrochloride

Isoxsuprine hydrochloride is a beta-adrenergic receptor agonist with Kis of 13.65 μΜ and 3.48 μΜ for myometrial and placcntal beta-adrenergic receptor, respectively. Isoxsuprine hydrochloride is also a NMDA receptor antagonist.

  • CAS Number: 579-56-6
  • MF: C18H24ClNO3
  • MW: 337.84100
  • Catalog: Adrenergic Receptor
  • Density: 1.146g/cm3
  • Boiling Point: 484.2ºC at 760mmHg
  • Melting Point: 203-204°
  • Flash Point: 246.6ºC

Efaroxan hydrochloride

Efaroxan hydrochloride is a potent and selective α2-adrenoceptor antagonist, antidiabetic activity. Efaroxan hydrochloride is a selective I1-Imidazoline receptor antagonist and can be used for the research of cardiovascular disease[1][2][3].

  • CAS Number: 89197-00-2
  • MF: C13H17ClN2O
  • MW: 252.740
  • Catalog: Adrenergic Receptor
  • Density: N/A
  • Boiling Point: 387ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 187.9ºC

DG5128

DG5128 is a preferential α2-adrenoceptor antagonist. DG5128 exhibits 7.4 times higher affinity (pKi=6.28) toward α2-adrenoceptor than α1-adrenoceptor.

  • CAS Number: 79689-25-1
  • MF: C16H19Cl2N3
  • MW: 324.24800
  • Catalog: Adrenergic Receptor
  • Density: N/A
  • Boiling Point: 460ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 232ºC

Epinephrine bitartrate

L-Epinephrine bitartrate is an α-adrenergic and β-adrenergic receptor agonist. L-Epinephrine is a hormone secreted by the medulla of the adrenal glands.

  • CAS Number: 51-42-3
  • MF: C13H19NO9
  • MW: 333.291
  • Catalog: Adrenergic Receptor
  • Density: N/A
  • Boiling Point: 413.1ºC at 760 mmHg
  • Melting Point: ~155 °C (dec.)
  • Flash Point: 207.9ºC

norfenefrine

Norfenefrine is an orally active, endogenously found α-adrenergic agonist and can be used for the research of female stress incontinence[1][2].

  • CAS Number: 536-21-0
  • MF: C8H11NO2
  • MW: 153.178
  • Catalog: Adrenergic Receptor
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 360.7±27.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 172.0±23.7 °C

Tolazoline hydrochloride

Tolazoline(NSC35110; Imidaline) Hcl is a non-selective competitive α-adrenergic receptor antagonist.IC50 value:Target: α-adrenoceptor antagonistTolazoline can be synthesized by the heterocyclation of the ethyl ester of iminophenzylacetic acid with ethylene diamine, which forms the desired product. The structure of tolazoline is strikingly similar to α-adrenergic agonists, which are antiedema sympathomimetics.

  • CAS Number: 59-97-2
  • MF: C10H13ClN2
  • MW: 196.677
  • Catalog: Adrenergic Receptor
  • Density: 1.09g/cm3
  • Boiling Point: 338.2ºC at 760mmHg
  • Melting Point: 172-176 °C
  • Flash Point: 158.3ºC

Amitraz

Amitraz is a non-systemic acaricide and insecticide, with alpha-adrenergic agonist activity, interaction with octopamine receptors of the central nervous system and inhibition of monoamine oxidases and prostaglandin synthesis.

  • CAS Number: 33089-61-1
  • MF: C19H23N3
  • MW: 293.406
  • Catalog: Adrenergic Receptor
  • Density: 1.0±0.1 g/cm3
  • Boiling Point: 450.7±55.0 °C at 760 mmHg
  • Melting Point: 86-87°C
  • Flash Point: 226.4±31.5 °C

Desglymidodrine

Desglymidodrine (ST 1059), the active metabolite of midodrine, is a selective α1-adrenoceptor agonist. Desglymidodrine is an effective arterial and venous vasoconstrictor and can be used to regulate blood pressure[1][2].

  • CAS Number: 3600-87-1
  • MF: C10H15NO3
  • MW: 197.23100
  • Catalog: Adrenergic Receptor
  • Density: N/A
  • Boiling Point: 364.3ºC at 760mmHg
  • Melting Point: 146-150ºC dec.
  • Flash Point: 174.1ºC

Methyldopate

Methyldopate is an ethyl ester prodrug of α-Methyldopa (α-MD; HY-B0225). Methyldopa (L-(-)-α-Methyldopa) is an α-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopate has the potential for severe hypertension research [1].

  • CAS Number: 6014-30-8
  • MF: C12H17NO4
  • MW: 239.268
  • Catalog: Adrenergic Receptor
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 398.0±37.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 194.5±26.5 °C