Adrenergic receptors are a class of G protein-coupled receptors that are targets of the catecholamines, especially norepinephrine and epinephrine. Many cells possess these receptors, and the binding of a catecholamine to the receptor will generally stimulate the sympathetic nervous system. The sympathetic nervous system is responsible for the fight-or-flight response, which includes widening the pupils of the eye, mobilizing energy, and diverting blood flow from non-essential organs to skeletal muscle. There are two main groups of adrenergic receptors, α and β, with several subtypes. α receptors have the subtypes α1 and α2. β receptors have the subtypes β1, β2 and β3. All three are linked to Gs proteins, which in turn are linked to adenylate cyclase. Agonist binding thus causes a rise in the intracellular concentration of the second messenger cAMP. Downstream effectors of cAMP include cAMP-dependent protein kinase (PKA), which mediates some of the intracellular events following hormone binding.


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Scopine

Scopine is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock. Target: α1-Adrenergic ReceptorScopine is a tropane alkaloid found in a variety of plants including Mandragora root, Senecio mikanoides (Delairea odorata), Scopolia carniolica and Scopolia lurida. Scopine can be prepared by the hydrolysis of scopolamine. From Wikipedia.

  • CAS Number: 498-45-3
  • MF: C8H13NO2
  • MW: 155.194
  • Catalog: Adrenergic Receptor
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 281.3±40.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 123.9±27.3 °C

Imiloxan hydrochloride

Imiloxan hydrochloride is a potent and selective alpha 2B-adrenoceptor antagonist. Imiloxan hydrochloride has the potential for acute kidney injury research[1][2].

  • CAS Number: 81167-22-8
  • MF: C14H17ClN2O2
  • MW: 280.75
  • Catalog: Adrenergic Receptor
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

LEVOBUNOLOL

Levobunolol (l-Bunolol) is a potent and nonselective β-adrenergic receptor antagonist. Levobunolol is an ocular hypotensive agent and lowers mean intraocular pressure (IOP). Levobunolol can be used for glaucoma and superior oblique myokymia (SOM) research[1][2][3].

  • CAS Number: 47141-42-4
  • MF: C17H25NO3
  • MW: 291.38500
  • Catalog: Adrenergic Receptor
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: 205 - 210ºC
  • Flash Point: N/A

(rac)-Nebivolol-d4

(Rac)-Nebivolol-d4 ((Rac)-R 065824-d4) is a labelled racemic Nebivolol. Nebivolol selectively inhibits β1- adrenergic receptor with IC50 of 0.8 nM[1][2].

  • CAS Number: 1219407-55-2
  • MF: C22H21D4F2NO4
  • MW: 409.46
  • Catalog: Adrenergic Receptor
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Esmolol-d7 (hydrochloride)

Esmolol-d7 hydrochloride is the deuterium labeled Esmolol hydrochloride. Esmolol hydrochloride is a beta adrenergic receptor blocker[1][2].

  • CAS Number: 1346598-13-7
  • MF: C16H19D7ClNO4
  • MW: 338.878
  • Catalog: Autophagy
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Dobutamine hydrochloride

Dobutamine Hcl(Dobutrex) is a sympathomimetic drug used in the treatment of heart failure and cardiogenic shock. Its primary mechanism is direct stimulation of β1 receptors of the sympathetic nervous system.

  • CAS Number: 49745-95-1
  • MF: C18H24ClNO3
  • MW: 337.841
  • Catalog: Adrenergic Receptor
  • Density: N/A
  • Boiling Point: 527.7ºC at 760mmHg
  • Melting Point: 184-186ºC(lit.)
  • Flash Point: 169.8ºC

Phentolamine

Phentolamine is a potent, selective and orally active α1 adrenergic and α2 adrenergic receptor antagonist. Phentolamine can be used for the treatment of erectile dysfunction[1][2][3].

  • CAS Number: 50-60-2
  • MF: C17H19N3O
  • MW: 281.352
  • Catalog: Adrenergic Receptor
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 551.0±45.0 °C at 760 mmHg
  • Melting Point: 177 - 178ºC
  • Flash Point: 287.0±28.7 °C

Navafenterol

Navafenterol (AZD-8871) is an inhaled dual-acting, potent, selective, and long-lasting M3-antagonist/β2-agonist (MABA) with long-lasting effects and favorable safety profile. The pIC50 is 9.5 for human M3 receptor, and the pEC50 is 9.5 for β2-adrenoceptor. Navafenterol can be used for the research of chronic obstructive pulmonary disease (COPD). Bronchoprotective and antisialagogue effects. Favorable cardiovascular profile[1].

  • CAS Number: 1435519-06-4
  • MF: C38H42N6O6S2
  • MW: 742.91
  • Catalog: Adrenergic Receptor
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

CL 316243 disodium salt

CL316243 is a highly potent selective β3-adrenoceptor agonist with a EC50 of 3 nM, but is an extremely poor to β1/2- receptors[1].CL316243 is a effective stimulant of adipocyte lipolysis and increases brown adipose tissue thermogenesis and metabolic rate[2]. CL316243 has the potential for the treatment obesity, diabetes and urge urinary incontinence[3].

  • CAS Number: 138908-40-4
  • MF: C20H18ClNNa2O7
  • MW: 465.79200
  • Catalog: Adrenergic Receptor
  • Density: N/A
  • Boiling Point: 689.5ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 370.8ºC

(+)-Sotalol

(+)-Sotalol ((S)-Sotalol) is the S-isomer of Sotalol (HY-103196). Sotalol is an orally active, non-selective β-adrenergic receptor blocker. (+)-Sotalol is an antiarrhythmic agent. (+)-Sotalol can prolong action potential duration in isolated cardiac muscle[1][2][3].

  • CAS Number: 30236-32-9
  • MF: C12H20N2O3S
  • MW: 272.36400
  • Catalog: Adrenergic Receptor
  • Density: 1.239g/cm3
  • Boiling Point: 443.3ºC at 760mmHg
  • Melting Point: N/A
  • Flash Point: 221.9ºC

Clenbuterol hydrochloride

Clenbuterol hydrochloride (NAB-365 hydrochloride) is a β2 adrenergic receptor agonist. It is a powerful bronchodilator withfat burning properties.

  • CAS Number: 21898-19-1
  • MF: C12H19Cl3N2O
  • MW: 313.651
  • Catalog: Adrenergic Receptor
  • Density: 1.25g/cm3
  • Boiling Point: 404.9ºC at 760 mmHg
  • Melting Point: 174-175.5°C
  • Flash Point: 198.7ºC

Bunazosin Hydrochloride

Bunazosin hydrochloride is a potent and selective α1-adrenoceptor antagonist. Bunazosin hydrochloride can be used for antihypertensive and ocular hypotensive research[1].

  • CAS Number: 52712-76-2
  • MF: C19H28ClN5O3
  • MW: 409.91
  • Catalog: Adrenergic Receptor
  • Density: 1.221g/cm3
  • Boiling Point: 620.6ºC at 760mmHg
  • Melting Point: 280-282°
  • Flash Point: 329.1ºC

Practolol

Practolol is a potent and selective β1-adrenergic receptor antagonist. Practolol can be used for the research of cardiac arrhythmias[1][2][3].

  • CAS Number: 6673-35-4
  • MF: C14H22N2O3
  • MW: 266.33600
  • Catalog: Adrenergic Receptor
  • Density: 1.0807 (rough estimate)
  • Boiling Point: 409.54°C (rough estimate)
  • Melting Point: 134-136° (BuOAc)
  • Flash Point: N/A

Isoxsuprine hydrochloride

Isoxsuprine hydrochloride is a beta-adrenergic receptor agonist with Kis of 13.65 μΜ and 3.48 μΜ for myometrial and placcntal beta-adrenergic receptor, respectively. Isoxsuprine hydrochloride is also a NMDA receptor antagonist.

  • CAS Number: 579-56-6
  • MF: C18H24ClNO3
  • MW: 337.84100
  • Catalog: Adrenergic Receptor
  • Density: 1.146g/cm3
  • Boiling Point: 484.2ºC at 760mmHg
  • Melting Point: 203-204°
  • Flash Point: 246.6ºC

DG5128

DG5128 is a preferential α2-adrenoceptor antagonist. DG5128 exhibits 7.4 times higher affinity (pKi=6.28) toward α2-adrenoceptor than α1-adrenoceptor.

  • CAS Number: 79689-25-1
  • MF: C16H19Cl2N3
  • MW: 324.24800
  • Catalog: Adrenergic Receptor
  • Density: N/A
  • Boiling Point: 460ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 232ºC

Epinephrine bitartrate

L-Epinephrine bitartrate is an α-adrenergic and β-adrenergic receptor agonist. L-Epinephrine is a hormone secreted by the medulla of the adrenal glands.

  • CAS Number: 51-42-3
  • MF: C13H19NO9
  • MW: 333.291
  • Catalog: Adrenergic Receptor
  • Density: N/A
  • Boiling Point: 413.1ºC at 760 mmHg
  • Melting Point: ~155 °C (dec.)
  • Flash Point: 207.9ºC

Amitraz

Amitraz is a non-systemic acaricide and insecticide, with alpha-adrenergic agonist activity, interaction with octopamine receptors of the central nervous system and inhibition of monoamine oxidases and prostaglandin synthesis.

  • CAS Number: 33089-61-1
  • MF: C19H23N3
  • MW: 293.406
  • Catalog: Adrenergic Receptor
  • Density: 1.0±0.1 g/cm3
  • Boiling Point: 450.7±55.0 °C at 760 mmHg
  • Melting Point: 86-87°C
  • Flash Point: 226.4±31.5 °C

Olanzapine

Olanzapine(LY170053) is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist.IC50 Value:Target: 5-HT ReceptorOlanzapine is a thienobenzodiazepine that blocks especially the serontonin (5-hydroxytryptamine [5-HT]) 5-HT2A and the dopamine D2 receptors (Ki values are 4 and 11 nM respectively) as well as muscarinic (M1), histamine (H1), 5-HT2C, 5-HT3 to 5-HT6, adrenergic (α(l)), and D4 receptors. Atypical antipsychotic for the treatment of schizophrenia. Olanzapine displays anticholinergic properties.

  • CAS Number: 132539-06-1
  • MF: C17H20N4S
  • MW: 312.432
  • Catalog: Apoptosis
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 476.0±55.0 °C at 760 mmHg
  • Melting Point: 195°C
  • Flash Point: 241.7±31.5 °C

Pronethalol-d6

Pronethalol-d6 ((±)-Pronethalo-d6) is the deuterium labeled Pronethalol. Pronethalol ((±)-Pronethalo) is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias and limits the cerebral arteriovenous malformation (AVMs)[1][2][3].

  • CAS Number: 1329805-79-9
  • MF: C15H13D6NO
  • MW: 235.35
  • Catalog: Adrenergic Receptor
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

(S)-timolol maleate

(S)-Timolol maleate, is a potent non-selective β-adrenergic receptor antagonist (Ki values are 1.97 and 2.0 nM for β1 and β2 receptor subtypes respectively). IC50 Value: 1.97 nM(Ki for β1); 2.0 nM(Ki for β2)Target: β-adrenergic receptor(S)-Timolol, 50% bioavailability following oral administration. Does not cross the blood brain barrier. Timolol maleate does appear to have some local anesthetic properties in human cornea after chronic use by susceptible individuals.

  • CAS Number: 26921-17-5
  • MF: C17H28N4O7S
  • MW: 432.492
  • Catalog: Adrenergic Receptor
  • Density: N/A
  • Boiling Point: 704.6ºC at 760 mmHg
  • Melting Point: 202-203 °C(lit.)
  • Flash Point: 380ºC

Adrenaline

L-Epinephrine is a hormone secreted by the medulla of the adrenal glands. L-Epinephrine is an α-adrenergic and β-adrenergic receptor agonist.

  • CAS Number: 51-43-4
  • MF: C9H13NO3
  • MW: 183.204
  • Catalog: Adrenergic Receptor
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 413.1±40.0 °C at 760 mmHg
  • Melting Point: 208-211ºC
  • Flash Point: 207.9±17.9 °C

Ro 363

Ro 363 is a potent and highly selective β1-adrenoceptor agonist. RO 363 is an effective inotropic stimulant, and is a cardiovascular modulator that reduces diastolic blood pressure and pronounces increases in myocardial contractility[1][2][3].

  • CAS Number: 74513-77-2
  • MF: C19H25NO6
  • MW: 363.40500
  • Catalog: Adrenergic Receptor
  • Density: 1.245g/cm3
  • Boiling Point: 600.3ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 316.8ºC

L-749372

L-749372 is the beta 3 adrenergic receptor 3-Pyridyloxypropanolamine agonist.

  • CAS Number: 159183-70-7
  • MF: C22H24IN3O4S
  • MW: 553.41
  • Catalog: Adrenergic Receptor
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

pimozide

Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5.

  • CAS Number: 2062-78-4
  • MF: C28H29F2N3O
  • MW: 461.546
  • Catalog: Adrenergic Receptor
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 649.0±65.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 346.3±34.3 °C

L-765,314

L-765314 is a potent and selective α1b adrenergic receptor antagonist with Kis of 5.4 nM and 2.0 nM for rat and human α1b adrenergic receptor, respectively.

  • CAS Number: 189349-50-6
  • MF: C27H34N6O5
  • MW: 522.59600
  • Catalog: Adrenergic Receptor
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Landiolol Hydrochloride

Landiolol hydrochloride (ONO1101 hydrochloride) is a highly beta1 selective ultra-short acting beta-blocker (β1/β2 selectivity = 255:1, a half-life of 4 min), acts as an adrenoceptor antagonist[1].

  • CAS Number: 144481-98-1
  • MF: C25H40ClN3O8
  • MW: 546.053
  • Catalog: Adrenergic Receptor
  • Density: 1.201g/cm3
  • Boiling Point: 727.5ºC at 760mmHg
  • Melting Point: 122-127ºC
  • Flash Point: 393.8ºC

Dipivefrin

Dipivefrin is a potent adrenergic agonist. Dipivefrin is an adrenergic pro-drug. Dipivefrin can be used for reduce IOP (intraocular pressure) in patients suffering from chronic open angle glaucoma[1][2].

  • CAS Number: 52365-63-6
  • MF: C19H29NO5
  • MW: 351.43700
  • Catalog: Adrenergic Receptor
  • Density: 1.097 g/cm3
  • Boiling Point: 473.7ºC at 760 mmHg
  • Melting Point: 146-147°
  • Flash Point: 240.3ºC

Silodosin-d4

Silodosin-d4 (KAD 3213-d4) is the deuterium labeled Silodosin. Silodosin (KAD 3213) is a potent, selective and orally active α1A-adrenergic receptor (α1A-AR) blocker. Silodosin exhibits high affinity for α1A-AR (Ki=0.036 nM), over 162-fold and 50-fold than for α1B-AR and α1D-AR with Ki values of 21 nM and 2.0 nM, respectively. Silodosin is an effective and well-tolerated agent, it can be used for the investigation of LUTS/BPH[1][3].

  • CAS Number: 1426173-86-5
  • MF: C25H28D4F3N3O4
  • MW: 499.559
  • Catalog: Adrenergic Receptor
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 601.4±55.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 317.5±31.5 °C

Phentolamine hydrochloride

Phentolamine hydrochloride is an orally active adrenergic α receptor-blocking agent[1].

  • CAS Number: 73-05-2
  • MF: C17H20ClN3O
  • MW: 317.813
  • Catalog: Adrenergic Receptor
  • Density: N/A
  • Boiling Point: 569ºC at 760 mmHg
  • Melting Point: >230ºC(dec.)
  • Flash Point: 297.9ºC

Imoxiterol

Imoxiterol is a β-adrenergic agonist.

  • CAS Number: 88578-07-8
  • MF: C20H25N3O3
  • MW: 355.43100
  • Catalog: Adrenergic Receptor
  • Density: 1.23g/cm3
  • Boiling Point: 590.3ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 310.8ºC