1229096-88-1

1229096-88-1 structure

Name: GSK 9027
Chemical Name: gsk9027
CAS Number: 1229096-88-1
Molecular Formula: C₂₇H₁₉F₄N₃O₂S
Molecular Weight: 525.51700
Catalog: Signaling Pathways GPCR/G Protein Glucocorticoid Receptor
Create Date: 2017-01-22 06:51:46
Modify Date: 2024-01-16 07:45:05
GSK9027, as a non-steroidal glucocorticoid receptor (GR) agonist, behaves as a partial agonist on the 2×glucocorticoid response element (GRE) reporter system, and achieves intrinsic activities relative to dexamethasone[1][2].

Name	gsk9027

Description	GSK9027, as a non-steroidal glucocorticoid receptor (GR) agonist, behaves as a partial agonist on the 2×glucocorticoid response element (GRE) reporter system, and achieves intrinsic activities relative to dexamethasone[1][2].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor
Target	GR[2]
In Vitro	GSK9027 demonstrates reduced 2×GRE reporter activation and is partial agonists[2].
References	[1]. Rider CF, et al. Cytokine-Induced Loss of Glucocorticoid Function: Effect of Kinase Inhibitors, Long-Acting β2-Adrenoceptor Agonist and Glucocorticoid Receptor Ligands. PLoS ONE. 2015; 10(1): e0116773. [2]. Rider, C. F., et al. TNF±-Induced Glucocorticoid Resistance: Inhibition Of Inflammatory Signalling And The Effect On Full And Partial GR Agonists. 2012