GSK 9027

Modify Date: 2024-01-16 07:45:05

GSK 9027 Structure
GSK 9027 structure
Common Name GSK 9027
CAS Number 1229096-88-1 Molecular Weight 525.51700
Density N/A Boiling Point N/A
Molecular Formula C27H19F4N3O2S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of GSK 9027


GSK9027, as a non-steroidal glucocorticoid receptor (GR) agonist, behaves as a partial agonist on the 2×glucocorticoid response element (GRE) reporter system, and achieves intrinsic activities relative to dexamethasone[1][2].

 Names

Name gsk9027

 GSK 9027 Biological Activity

Description GSK9027, as a non-steroidal glucocorticoid receptor (GR) agonist, behaves as a partial agonist on the 2×glucocorticoid response element (GRE) reporter system, and achieves intrinsic activities relative to dexamethasone[1][2].
Related Catalog
Target

GR[2]

In Vitro GSK9027 demonstrates reduced 2×GRE reporter activation and is partial agonists[2].
References

[1]. Rider CF, et al. Cytokine-Induced Loss of Glucocorticoid Function: Effect of Kinase Inhibitors, Long-Acting β2-Adrenoceptor Agonist and Glucocorticoid Receptor Ligands. PLoS ONE. 2015; 10(1): e0116773.

[2]. Rider, C. F., et al. TNF±-Induced Glucocorticoid Resistance: Inhibition Of Inflammatory Signalling And The Effect On Full And Partial GR Agonists. 2012

 Chemical & Physical Properties

Molecular Formula C27H19F4N3O2S
Molecular Weight 525.51700
Exact Mass 525.11300
PSA 72.37000
LogP 7.94610
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