1286281-32-0

1286281-32-0 structure

Name: NH2-PEG6-Boc
Chemical Name: tert-butyl 1-amino-3,6,9,12,15,18-hexaoxahenicosan-21-oate
CAS Number: 1286281-32-0
Molecular Formula: C₁₉H₃₉NO₈
Molecular Weight: 409.51500
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2017-03-22 02:07:52
Modify Date: 2025-08-20 21:26:34
NH2-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG6-Boc is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

Name	tert-butyl 1-amino-3,6,9,12,15,18-hexaoxahenicosan-21-oate
Synonyms	H2N-PEG6-tBu Amino-PEG6-t-butyl ester

Description	NH2-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG6-Boc is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Alkyl/ether Non-cleavable
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
References	[1]. Foley CA, et al. Assessing the Cell Permeability of Bivalent Chemical Degraders Using the Chloroalkane Penetration Assay. ACS Chem Biol. 2020 Jan 17;15(1):290-295. [2]. Kenneth John DIRICO, et al. Spliceostatin analogs. WO2014068443A1.