NH2-PEG6-Boc
Modify Date: 2024-01-09 09:45:07
NH2-PEG6-Boc structure
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Common Name | NH2-PEG6-Boc | ||
|---|---|---|---|---|
| CAS Number | 1286281-32-0 | Molecular Weight | 409.51500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H39NO8 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NH2-PEG6-BocNH2-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG6-Boc is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. |
| Name | tert-butyl 1-amino-3,6,9,12,15,18-hexaoxahenicosan-21-oate |
|---|---|
| Synonym | More Synonyms |
| Description | NH2-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG6-Boc is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. |
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| Related Catalog | |
| Target |
PEGs Alkyl/ether Non-cleavable |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2]. |
| References |
[2]. Kenneth John DIRICO, et al. Spliceostatin analogs. WO2014068443A1. |
| Molecular Formula | C19H39NO8 |
|---|---|
| Molecular Weight | 409.51500 |
| Exact Mass | 409.26800 |
| PSA | 107.70000 |
| LogP | 1.47680 |
| H2N-PEG6-tBu |
| Amino-PEG6-t-butyl ester |