NH2-PEG6-Boc

Modify Date: 2024-01-09 09:45:07

NH2-PEG6-Boc Structure
NH2-PEG6-Boc structure
Common Name NH2-PEG6-Boc
CAS Number 1286281-32-0 Molecular Weight 409.51500
Density N/A Boiling Point N/A
Molecular Formula C19H39NO8 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of NH2-PEG6-Boc


NH2-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG6-Boc is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

 Names

Name tert-butyl 1-amino-3,6,9,12,15,18-hexaoxahenicosan-21-oate
Synonym More Synonyms

 NH2-PEG6-Boc Biological Activity

Description NH2-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG6-Boc is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
Related Catalog
Target

PEGs

Alkyl/ether

Non-cleavable

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
References

[1]. Foley CA, et al. Assessing the Cell Permeability of Bivalent Chemical Degraders Using the Chloroalkane Penetration Assay. ACS Chem Biol. 2020 Jan 17;15(1):290-295.

[2]. Kenneth John DIRICO, et al. Spliceostatin analogs. WO2014068443A1.

 Chemical & Physical Properties

Molecular Formula C19H39NO8
Molecular Weight 409.51500
Exact Mass 409.26800
PSA 107.70000
LogP 1.47680

 Synonyms

H2N-PEG6-tBu
Amino-PEG6-t-butyl ester
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