959841-49-7

959841-49-7 structure

Name: (E)-Akt inhibitor-IV
Chemical Name: 1H-Benzimidazolium, 6-(2-benzothiazolyl)-1-ethyl-2-[(1E)-2-(methylphenylamino)ethenyl]-3-phenyl-, iodide
CAS Number: 959841-49-7
Molecular Formula: C₃₁H₂₇IN₄S
Molecular Weight: 614.54200
Catalog: Signaling Pathways PI3K/Akt/mTOR Akt
Create Date: 2016-05-28 23:58:14
Modify Date: 2024-01-12 19:29:04
(E)-Akt inhibitor-IV ((E)-AKTIV) is a PI3K-Akt inhibitor, with potent cytotoxic[1].

Name	1H-Benzimidazolium, 6-(2-benzothiazolyl)-1-ethyl-2-[(1E)-2-(methylphenylamino)ethenyl]-3-phenyl-, iodide
Synonyms	AKT inhibitor IV AKT INHIBITOR IV

Description	(E)-Akt inhibitor-IV ((E)-AKTIV) is a PI3K-Akt inhibitor, with potent cytotoxic[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> Akt
Target	Akt[1]
In Vitro	(E)-Akt inhibitor-IV (compound 7) exhibits average GI20 of 0.04 μM on four cell lines (MDA-MB468 cells, MDA-MB231 cells, MCF7 cells and 184B5 cells)[1]. (E)-Akt inhibitor-IV shows little effects on the growth of 184B5 non-cancer cells at the average GI20 doses[1].
References	[1]. Changkun Hu, et al. A 4-aminoquinoline derivative that markedly sensitizes tumor cell killing by Akt inhibitors with a minimum cytotoxicity to non-cancer cells. Eur J Med Chem. 2010 Feb;45(2):705-9.