902464-46-4

902464-46-4 structure

Name: UBP 310
Chemical Name: 1(2H)-Pyrimidinepropanoic acid, α-amino-3-[(2-carboxy-3-thienyl)methyl]-3,4-dihydro-5-methyl-2,4-dioxo-, (αS)
CAS Number: 902464-46-4
Molecular Formula: C₁₄H₁₅N₃O₆S
Molecular Weight: 353.35000
Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
Create Date: 2016-10-16 09:34:19
Modify Date: 2024-01-02 22:42:07
UBP310 is a selective GluR5 antagonist, with a Kd of 130 nM[1].

Name	1(2H)-Pyrimidinepropanoic acid, α-amino-3-[(2-carboxy-3-thienyl)methyl]-3,4-dihydro-5-methyl-2,4-dioxo-, (αS)

Description	UBP310 is a selective GluR5 antagonist, with a Kd of 130 nM[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
Target	GluR5[1]
In Vitro	UBP310 binds to GluR5 S1S2 with an affinity of 130 nM and shows 12,700-fold selectivity for GluR5 versus GluR6 and 830-fold selectivity for GluR5 versus GluR2[1].
References	[1]. Mark L Mayer, et al. Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists. J Neurosci. 2006 Mar 15;26(11):2852-61.